Serpasil

Dosage Forms & Strengths

tablet

• 0.1mg
• 0.25mg

Hypertension

Initial

• 0.5 mg daily for 1 or 2 weeks

Maintenance

• 0.1-0.25 mg PO qDay
• Use higher dosages cautiously occurrence of mental depression or other adverse reactions may increase

Psychiatric Disorders

0.5 mg daily, but may range from 0.1 to 1 mg; titrate dose according to patient response

Tardive Dyskinesia

0.25 mg q6hr; may increase by 0.1-0.25 mg to a total of 5 mg daily

Dosage Forms & Strengths

tablet

• 0.1mg
• 0.25mg

Hypertension

0.02 mg/kg/day PO qDay or divided q12hr, not to exceed 0.25 mg/day 

Adverse CNS effects; may cause bradycardia and orthostatic hypotension; not recommended as routine treatment for hypertension (Beers criteria)

0.05 mg PO qDay; may increase by 0.05 mg after 1 week as needed; not to exceed 0.1 mg/day

Frequency Not Defined

Angina

Bradycardia

Anorexia

Peripheral edema

Syncope

Premature ventricular contractions

Dizziness

Depression

Lethargy

Pruritus

Weight gain

Thrombocytopenia purpura

Gynecomastia

Rash

Nightmare

Nervousness

Paradoxical anxiety

Tardive dyskinesia

GI hypersecretion

Impotence

Blurred vision

Optic atrophy

Decreased libido

Nasal congestion

Contraindications

Hypersensitivity, active peptic ulcer, ulcerative colitis, history of depression, history of gallstones; electroconvulsive treatment within 1 week

Cautions

Use caution in asthma, gallstones, Parkinson's disease, renal impairment, inflammatory bowel disease or history of peptic ulcer disease

Significant mental depression may occur with high doses

Use caution in patients at risk of hypotension

History of gall stones, PUD, ulcerative colitis

Breastfeeding

Avoid during breast-feeding

Serpasil is part of the drug class:

• Rauwolfia alkaloids