Temozolomide Injection

Before receiving temozolomide,

• tell your doctor and pharmacist if you are allergic to temozolomide, dacarbazine (DTIC-Dome) any other medications, or any of the ingredients in temozolomide injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: carbamazepine (Carbatrol, Epitol, Tegretol); co-trimoxazole (Bactrim, Septra); phenytoin (Dilantin, Phenytek); steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); and valproic acid (Stavzor, Depakene).
• tell your doctor if you have or have ever had kidney or liver disease.
• you should know that temozolomide may interfere with sperm production in men. However, you should not assume that you cannot get someone else pregnant. Tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. You or your partner should not become pregnant while you are receiving temozolomide. Use a reliable method of birth control to prevent pregnancy. If you become pregnant while receiving temozolomide, call your doctor. Temozolomide may harm the fetus.
• tell your doctor if you are breast-feeding. You should not breastfeed while you are receiving temozolomide.

• It is used to treat brain cancer.
• It may be given to you for other reasons. Talk with the doctor.

Use temozolomide injection as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
• Any unexplained bruising or bleeding.
• Shortness of breath, a big weight gain, or swelling in the arms or legs.
• Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
• Feeling confused.
• Mood changes.
• Trouble swallowing.
• Not able to control bladder.
• Memory problems or loss.
• A burning, numbness, or tingling feeling that is not normal.
• Seizures.
• Very bad headache.
• Change in eyesight.
• Pinpoint red spots on the skin.
• Very bad and sometimes deadly liver problems have happened with this medicine. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
• This medicine may lower the ability of your bone marrow to make blood cells that your body needs. A very bad and sometimes deadly type of anemia has happened. Call your doctor right away if you have pale skin or feel very tired or weak.
• Irritation or swelling where the shot was given.
• Pain where the shot was given.

• If you need to store temozolomide injection at home, talk with your doctor, nurse, or pharmacist about how to store it.