Pegaptanib

Name: Pegaptanib

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Pegaptanib Drug Class

Pegaptanib is part of the drug class:

  • Antineovascularisation agents

Pegaptanib Overdose

If pegaptanib is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.  

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad headache.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Trouble passing urine.
  • Pain when passing urine.
  • Eyelid swelling.
  • Eye redness.
  • Eye discharge.
  • Bleeding in the eye.
  • Eye is bothered by bright light.

What are some other side effects of Pegaptanib?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Eye irritation.
  • Seeing floaters.
  • Dizziness.
  • Loose stools (diarrhea).
  • Headache.
  • Upset stomach.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Intraocular [preservative free]:

Macugen: 0.3 mg (0.09 mL)

Dosing Renal Impairment

There are no dosage adjustments provided in the manufacturer’s labeling.

Drug Interactions

Pegloticase: May diminish the therapeutic effect of Pegaptanib. Monitor therapy

Monitoring Parameters

Optic nerve head perfusion (immediately after injection), intraocular pressure (within 30 minutes and during the week after injection); signs of infection/inflammation (for first week following injection) or hypersensitivity; retinal perfusion, endophthalmitis, visual acuity

Pregnancy Risk Factor B Pregnancy Considerations

Adverse events have not been observed in animal reproduction studies.

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