Pennyroyal

Name: Pennyroyal

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Pennyroyal side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using pennyroyal and call your healthcare provider at once if you have:

  • seizures;

  • vision or hearing problems; or

  • breathing difficulty.

Common side effects may include:

  • stomach pain, nausea, vomiting;

  • burning of the throat; or

  • fever.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Uses

Pennyroyal has been used as an insect repellent, antiseptic, fragrance, flavoring, as an emmenagogue, carminative, stimulant, antispasmodic and for bowel disorders, skin eruptions and pneumonia.

Pregnancy/Lactation

Documented adverse effects. Avoid use. Abortifacient, hepatotoxic, and neurotoxic.

Interactions

None well documented.

Toxicology

In large portions, pennyroyal can cause abortion, irreversible renal damage, severe liver damage and death. A small amount of oil can produce delirium, unconsciousness, shock, seizures and auditory and visual hallucinations.

Botany

Both plants are members of the mint family and both are referred to as pennyroyal. H. pulegioides (American pennyroyal) grows in woods through most of the northern and eastern United States and Canada while M. pulegium is found in parts of Europe. Pennyroyal is a perennial, creeping herb that possesses small, lilac flowers at the stem ends. It can grow to be 30 to 50 cm in height. The leaves are grayish green and, like other mint family members, are very aromatic. 1 , 2

Bibliography

1. Low T, et al. eds. Pennyroyal. Magic and Medicine of Plants . Sydney, Australia: Reader's Digest, 1994;278.
2. Lawless J. Pennyroyal. The Illustrated Encyclopedia of Essential Oils . Rockport, MA: Element Books, Inc., 1995;176.
3. Da Legnano LP. The Medicinal Plants . Rome, Italy: Edizioni Mediterranee, 1973.
4. Tyler VE. The New Honest Herbal . Philadelphia, PA: G.F. Stickley Co., 1987.
5. Thomassen D, et al. J Pharmacol Exp Ther . 1990;253:567.
6. Newall C, et al. Pennyroyal. Herbal Medicines . London, England: Pharmaceutical Press, 1996;208.
7. Duke J. Hedeoma Pulegioides . CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press Inc., 1989;223,307–308.
8. Montes M, et al. Annales Pharmaceutiques Francaises . 1986;44:133–136.
9. Thomassen D, et al. Drug Metab Dispos . 1991;19:997–1003.
10. Sullivan JB Jr., Rumack BH, Thomas H Jr., Peterson RG, Bryson P. Pennyroyal oil poisoning and hepatotoxicity. JAMA . 1979;242:2873-2874.
11. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook . Boca Raton, FL:CRC Press;1997.
12. Newall CA, Anderson LA, Phillipson JD, eds. Herbal Medicines: A Guide for Health-Care Professionals . London:Pharmaceutical Press;1996.
13. Ernst E. Herbal medicinal products during pregnancy: are they safe? BJOG . 2002;109:227-235.
14. Early DF. Lancet . 1961;2:580.
15. Gordon WP, et al. Drug Metab Disp . 1987;15:589.
16. Gordon WP, et al. Toxicol Appl Pharmacol . 1982;65:413.
17. Buechel DW, et al. J Am Osteopath Assn . 1983;2:793.
18. Thomassen D, et al. J Pharmacol Exp Ther . 1988;244:825–829.
19. Carmichael P. Ann Intern Med . 1997;126:250–251.
20. Mizutani T, et al. Res Commun Chem Pathol Pharmacol . 1987;58:75–83.
21. Olsen P, Thorup I. Arch Toxicol . 1984;7(Suppl):408.
22. Sudekum M, et al. J Am Vet Med Assoc . 1992;200:817–818.
23. Bakerink J, et al. Pediatrics . 1996;98:944–947.
24. Anderson I, et al. Ann Intern Med . 1996;124:726–734.
25. Mack R. NC Med J . 1997;58:456–457.
26. Allen WT. Lancet . 1897;2:1022.
27. Black D. J Am Osteopath Assoc . 1985;85:282.

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