Pentetate Calcium Trisodium

Ca-DTPA is indicated for treatment of individuals with known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination.

1000 mg / 5 mL single-use ampoules.

Adequate and well-controlled drug-drug interaction studies in humans were not identified in the literature. When an individual is contaminated with multiple radiocontaminants, or when the radiocontaminants are unknown, additional therapies may be needed (e.g., Prussian blue, potassium iodide).

Instruct patients to:

• drink plenty of fluids and void frequently to promote dilution of the radioactive chelate in the urine and minimize radiation exposure directly to the bladder.
• use a toilet instead of a urinal, and flush several times after each use.
• clean up spilled urine or feces completely and wash hands thoroughly. Wash clothing or linens separately if blood or urine comes in contact.
• dispose of any expectorant carefully. Avoid swallowing the expectorant if possible.

Instruct parents and child-care givers to take extra precaution in handling the urine, feces, and expectorants of children to avoid any additional exposure to either the care-giver or to the child.

Instruct nursing mothers to take extra precaution in disposing of breast milk. [See Use in Specific Populations (8.3)]

Pentetate Calcium Trisodium (PEN-te-tate Kal-see-um try-SOE-dee-um)is used to remove harmful substances, such as plutonium, americium, or curium from your body.

This medicine is available only with your doctor's prescription, in the following dosage forms:

Inhalation
• Inhalation solution (U.S.)

Parenteral
• Injection (U.S.)

To prevent radiation contamination of other persons or environment:

• Using a normal toilet instead of a urinal
• Flushing toilet several times after each use
• Completely cleaning up any spilled urine with a tissue and flushing it away
• Washing hands thoroughly with soap after urinating or a bowel movement
• Immediately laundering clothes and linens soiled with urine, feces or blood; washing them separately from other clothes

Avoid swallowing any solid substances that may be coughed up. Dispose of solid substances in sink or toilet. Flush several times if put in toilet or flush sink by washing hands thoroughly with soap after disposal.

Extra precaution in handling urine, feces, and substances coughed up by children to avoid additional exposure to the care-giver or to the child.

If you are breast-feeding your baby, talk to your doctor about how long you must formula feed your baby and how to dispose of the breast milk containing harmful substances..

12 years and older:
Initial dose: 1 gram, intravenously
Maintenance dose (if pentetate zinc disodium is unavailable): 1 gram, intravenously
Maximum dose: 1 dose per 24 hour period

Under 12 years:
Initial dose: 14 mg/kg (not to exceed 1 gram), intravenously
Maintenance dose (if pentetate zinc disodium is unavailable): 14 mg/kg (not to exceed 1 gram), intravenously
Maximum dose: 1 dose per 24 hour period

Comments:
-Administer during the first 24 hours after internal contamination; it is more effective than pentetate zinc disodium during this period.
-If additional chelation is indicated, pentetate zinc disodium is the preferred agent.
-May use for additional chelation if pentetate zinc disodium is not available; administer concomitant mineral supplements containing zinc.

Use: Treatment of known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination.

Data not available

No adjustment recommended

-Dialysis may be used to increase the rate of elimination in heavily contaminated patients.
-High efficiency flux dialysis is recommended.
-Dialysis fluid will become radioactive; use radiation precautions to protect others.