Penicillin G Benzathine and Penicillin G Procaine

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Fever or chills.
• Swelling.
• Joint pain.
• Very bad dizziness or passing out.
• Feeling very tired or weak.
• Any unexplained bruising or bleeding.
• It is common to have diarrhea when taking penicillin G benzathine and penicillin G procaine. Rarely, a very bad form of diarrhea called Clostridium difficile (C diff)–associated diarrhea (CDAD) may occur. Sometimes, this has led to a deadly bowel problem (colitis). CDAD may happen while you are taking this medicine or within a few months after you stop taking it. Call your doctor right away if you have stomach pain or cramps, very loose or watery stools, or bloody stools. Do not try to treat loose stools without first checking with your doctor.
• Nerve damage can happen if penicillin G benzathine and penicillin G procaine is given into or near a nerve. This could be long-lasting. Call your doctor right away if you have any numbness, tingling, or weakness.

• Pen G Benz/Pen G Procaine
• Penicillin G Procaine and Benzathine Combined
• Penicillin G Procaine/Benzath

• Antibiotic, Penicillin

Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs); which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Absorption

IM: Released slowly

Distribution

Highest levels in the kidney; lesser amounts in liver, skin, intestines

Time to Peak

Serum: IM: Within 3 hours

Protein Binding

~60%

Hypersensitivity to penicillin(s), procaine, or any component of the formulation

There are no dosage adjustments provided in manufacturer's labeling.

There are no dosage adjustments provided in manufacturer's labeling.