PEG-3350 with Electolytes

You should not use this medicine if you are allergic to polyethylene glycol or any other electrolyte solutions (such as Pedialyte or Gatorade), or if you have:

• a perforated bowel;

• a bowel obstruction or severe constipation; or

• colitis or toxic megacolon.

Polyethylene glycol electrolyte solution can cause dangerous or life-threatening side effects in people with these conditions.

People with eating disorders (such as anorexia or bulimia) should not use this medication without the advice of a doctor.

To make sure polyethylene glycol electrolyte solution is safe for you, tell your doctor if you have:

• heart disease;

• trouble swallowing;

• nausea or vomiting;

• a stomach disorder such as gastroesophageal reflux disease (GERD) or slow digestion;

• kidney disease;

• a history of seizures;

• low levels of sodium in your blood;

• a history of bowel obstruction, diverticulitis, ulcerative colitis, or other chronic bowel disease;

• if you take any medications; or

• if you have recently used alcohol.

FDA pregnancy category C. It is not known whether polyethylene glycol electrolyte solution will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether polyethylene glycol electrolyte solution passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Moviprep contains phenylalanine. Talk to your doctor before using if you have phenylketonuria (PKU).

Polyethylene glycol electrolyte solution is a powder medicine that must be mixed with water before using it. Follow all directions on your medicine label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not add any flavorings to this medicine, such as sugar, honey, artificial sweetener, fruit juices, or other beverages.

Do not take polyethylene glycol electrolyte solution if it has been less than 1 hour since you last ate solid food. For best results, take the medicine 2 to 4 hours after you last ate.

Store unmixed medicine at room temperature away from moisture and heat.

Store the mixed medicine in a refrigerator in an upright position.

Drink plenty of clear liquids (such as water, broth, black coffee, tea, clear soda) before, during, and after your treatment. Avoid foods and beverages that contain pulp or are red or purple in color. You may also eat popsicles (not fruit bars or fudge bars) or gelatin without fruit pieces or toppings.

This medicine comes with instructions about when and what to eat or drink on your first day of treatment. Each brand may have different instructions.

Shake the liquid well just before you measure a dose. Drink this medicine in the exact portions at the exact time intervals prescribed by your doctor.

The usual dose of the medication is 8 ounces every 10 to 15 minutes. Drink each portion as quickly as possible, rather than sipping it slowly. The first watery stool should appear within 1 hour after you start drinking polyethylene glycol electrolyte solution.

Polyethylene glycol electrolyte solution will produce watery diarrhea. Keep taking the medicine until your stool is watery and clear. In most cases, at least 3 liters of polyethylene glycol electrolyte solution is needed for the full effect.

Throw away any polyethylene glycol electrolyte solution you have not used within 24 to 48 hours after it was mixed (follow directions for your specific brand of this medicine).

Do not eat or drink anything within 2 hours before your medical test.

Other drugs may interact with polyethylene glycol electrolyte solution, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

• Your pharmacist can provide more information about polyethylene glycol electrolyte solution.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.02.

Date modified: October 13, 2017
Last reviewed: February 12, 2014

Applies to polyethylene glycol 3350 with electrolytes: oral powder for solution

Other dosage forms:

• oral powder for solution, oral powder for suspension

Along with its needed effects, polyethylene glycol 3350 with electrolytes (the active ingredient contained in PEG-3350 with Electolytes) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking polyethylene glycol 3350 with electrolytes:

• Full or bloated feeling
• pain in the upper stomach
• pressure in the stomach
• stomach pain
• swelling of abdominal or stomach area
• vomiting

• Coma
• confusion
• convulsions
• decreased urine output
• dizziness
• dry mouth
• fast or irregular heartbeat
• headache
• increased thirst
• loss of appetite
• muscle pain or cramps
• numbness or tingling in the hands, feet, fingertips, lips, or mouth
• shortness of breath
• swelling of the face, ankles, or hands
• unusual tiredness or weakness

Some side effects of polyethylene glycol 3350 with electrolytes may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Burning, itching, or pain around the anus
• difficulty with sleeping
• feeling unusually cold
• general feeling of discomfort or illness
• hunger
• nausea
• shivering
• thirst

• Acid or sour stomach
• belching
• heartburn
• indigestion
• stomach discomfort or upset

Applies to polyethylene glycol 3350 with electrolytes: oral kit, oral powder for reconstitution

General

The most common adverse events were abdominal distension, anal discomfort, thirst, nausea, and abdominal pain. Since diarrhea is considered part of the efficacy of this product, it was not defined as an adverse reaction.[Ref]

Gastrointestinal

Very common (10% or more): Abdominal distension (59.8%), anal discomfort (52%), nausea (47.3%), abdominal pain (39.1%), vomiting (12.8%)
Common (1% to 10%): Upper abdominal pain, dyspepsia
Frequency not reported: Upper gastrointestinal bleeding from a Mallory-Weiss tear, esophageal perforation, borborygmi, flatulence[Ref]

Metabolic

Very common (10% or more): Hunger (70.8%)
Common (1% to 10%): Hypokalemia, hyperphosphatemia
Frequency not reported: Electrolyte disturbances, hyperkalemia[Ref]

Other

Very common (10% or more): Rigors (33.7%), malaise (26.6%)
Frequency not reported: Peripheral edema[Ref]

Nervous system

Very common (10% or more): Dizziness (18.1%)
Common (1% to 10%): Headache[Ref]

Psychiatric

Very common (10% or more): Sleep disorder (34.9%)[Ref]

Hypersensitivity

Frequency not reported: Anaphylactic reaction
Postmarketing reports: Hypersensitivity reactions (including anaphylaxis, rash, angioedema, urticaria, lip and facial swelling, dyspnea, chest tightness, throat tightness)[Ref]

Cardiovascular

Frequency not reported: Asystole[Ref]

Dermatologic

Frequency not reported: Urticaria, dermatitis[Ref]

Respiratory

Frequency not reported: Rhinorrhea, acute pulmonary edema, acute pulmonary edema after aspirating the PEG-based preparation[Ref]

Some side effects of PEG-3350 with Electolytes may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.