Mechlorethamine (Systemic)

• It is used to treat cancer.
• It may be given to you for other reasons. Talk with the doctor.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Loose stools (diarrhea).
• Not hungry.
• Upset stomach or throwing up.
• Feeling tired or weak.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

(me klor ETH a meen)

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution Reconstituted, Injection, as hydrochloride:

Mustargen: 10 mg (1 ea)

Hodgkin lymphoma: Palliative treatment of Hodgkin lymphoma

Malignant effusion: Palliative treatment of effusions from metastatic carcinomas

Additional approved uses (manufacturer labeling): Treatment of lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma

No dosage adjustment provided in manufacturer’s labeling.

The following have also been reported:

Mild-to-moderate impairment: No dosage adjustment necessary (Ecklund, 2005).

Severe liver impairment: No dosage adjustment necessary; concomitant chemotherapy may require alteration until improvement in hepatic function (Ecklund, 2005)

Must be prepared immediately before use; degradation begins shortly after dilution. Dilute powder with 10 mL SWFI or NS to a final concentration of 1 mg/mL. May be further diluted in 50-100 mL NS for intracavitary administration.

Frequency not defined.

Cardiovascular: Local thrombophlebitis

Central nervous system: Brain disease (high dose), drowsiness, headache, lethargy, metallic taste, sedation, vertigo

Dermatologic: Alopecia, diaphoresis, erythema multiforme, maculopapular rash, skin rash

Endocrine & metabolic: Amenorrhea, hyperuricemia, oligomenorrhea

Gastrointestinal: Anorexia, diarrhea, mucositis, nausea, vomiting

Genitourinary: Inhibition of spermatogenesis

Hepatic: Jaundice

Hematologic & oncologic: Agranulocytosis, granulocytopenia (onset: 6 to 8 days; recovery: 10 to 21 days), hemolytic anemia, leukopenia, lymphocytopenia, pancytopenia, petechia, thrombocytopenia

Hypersensitivity: Anaphylaxis, hypersensitivity reaction

Infection: Herpes zoster

Neuromuscular & skeletal: Weakness

Ophthalmic: Lacrimation

Otic: Deafness, tinnitus

Miscellaneous: Fever, tissue necrosis (extravasation)

Adverse events have been observed in animal reproduction studies. Women of childbearing potential are advised not to become pregnant during treatment. [U.S. Boxed Warning]: Avoid exposure during pregnancy.