Blinatumomab (Intravenous Route)

Blinatumomab injection is used to treat Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL) after other medicines did not work well. Leukemia is a type of cancer where the body makes abnormal white blood cells.

Blinatumomab injection is an antineoplastic (cancer) medicine. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal cells may also be affected by blinatumomab, other side effects can occur. Before you begin treatment, talk to your doctor about the benefits of this medicine as well as the possible risks of using it.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

• Powder for Solution

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of blinatumomab injection in children.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil
• Aminophylline
• Artemether
• Astemizole
• Carbamazepine
• Cisapride
• Cyclosporine
• Dihydroergotamine
• Ergotamine
• Fentanyl
• Fosphenytoin
• Iloperidone
• Lumefantrine
• Paclitaxel
• Phenytoin
• Pimozide
• Quinidine
• Sirolimus
• Tacrolimus
• Terfenadine
• Theophylline
• Warfarin

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Encephalopathy or
• Liver disease or
• Neutropenia (low number of white blood cells) or
• Pancreatitis (inflammation of the pancreas) or
• Seizures, history of—Use with caution. May make these conditions worse.

• Infections—May decrease your body's ability to fight infections.