Bortezomib (Intravenous Route, Subcutaneous Route)

Name: Bortezomib (Intravenous Route, Subcutaneous Route)

US Brand Name

  1. Velcade

Pregnancy

Information about this bortezomib-intravenous-route-subcutaneous-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Varicella Virus Vaccine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Cholera Vaccine, Live
  • Fosphenytoin
  • Influenza Virus Vaccine, Live
  • Phenytoin
  • Poliovirus Vaccine, Live
  • Rifabutin
  • Rifapentine
  • Smallpox Vaccine
  • St John's Wort
  • Typhoid Vaccine
  • Yellow Fever Vaccine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ketoconazole

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to boron or
  • Allergy to mannitol—Should not be used in patients with these conditions.
  • Congestive heart failure or
  • Dehydration or
  • Heart disease or
  • Lung disease (eg, acute respiratory distress syndrome, lung infiltration, pneumonitis, pulmonary hypertension) or
  • Peripheral neuropathy (nerve problem) or
  • Syncope (fainting), history of—Use with caution. May make these conditions worse.
  • Herpes zoster (shingles)—May reactivate this condition.
  • Liver disease, moderate to severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
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