Bismuth Subsalicylate, Metronidazole, And Tetracycline (Oral Route)

Appropriate studies have not been performed on the relationship of age to the effects of Helidac® in the pediatric population. Safety and efficacy have not been established.

Tetracycline may cause permanent discoloration of the teeth and slow down the growth of bones. This medicine should not be given to children 8 years of age and younger unless directed by the child's doctor.

Although appropriate studies on the relationship of age to the effects of Helidac® therapy have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving Helidac®.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Acitretin
• Amifampridine
• Amisulpride
• Amprenavir
• Bepridil
• Cisapride
• Disulfiram
• Dronabinol
• Dronedarone
• Mesoridazine
• Methoxyflurane
• Pimozide
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aceclofenac
• Acemetacin
• Alfuzosin
• Amiodarone
• Amitriptyline
• Amoxicillin
• Ampicillin
• Amtolmetin Guacil
• Anagrelide
• Apomorphine
• Aripiprazole
• Arsenic Trioxide
• Asenapine
• Astemizole
• Atazanavir
• Azithromycin
• Bacampicillin
• Bedaquiline
• Bexarotene
• Bromfenac
• Bufexamac
• Bupropion
• Buserelin
• Busulfan
• Capecitabine
• Celecoxib
• Chloroquine
• Chlorpromazine
• Cholera Vaccine, Live
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clomipramine
• Clonixin
• Cloxacillin
• Clozapine
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Dexibuprofen
• Dexketoprofen
• Diclofenac
• Dicloxacillin
• Digoxin
• Dipyrone
• Disopyramide
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Doxifluridine
• Droperidol
• Droxicam
• Ebastine
• Efavirenz
• Eribulin
• Erythromycin
• Escitalopram
• Etodolac
• Etofenamate
• Etoricoxib
• Etretinate
• Famotidine
• Felbamate
• Felbinac
• Fenoprofen
• Fepradinol
• Feprazone
• Fingolimod
• Flecainide
• Floctafenine
• Fluconazole
• Flufenamic Acid
• Fluorouracil
• Fluoxetine
• Flurbiprofen
• Formoterol
• Foscarnet
• Fosphenytoin
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibuprofen
• Ibutilide
• Iloperidone
• Imipramine
• Indomethacin
• Isotretinoin
• Itraconazole
• Ivabradine
• Ketoconazole
• Ketoprofen
• Lapatinib
• Leuprolide
• Levofloxacin
• Lornoxicam
• Loxoprofen
• Lumefantrine
• Lumiracoxib
• Mebendazole
• Meclofenamate
• Mefenamic Acid
• Mefloquine
• Meloxicam
• Methadone
• Methicillin
• Mifepristone
• Mizolastine
• Morniflumate
• Moxifloxacin
• Mycophenolate Mofetil
• Mycophenolic Acid
• Nabumetone
• Nafarelin
• Nafcillin
• Naproxen
• Nelfinavir
• Nepafenac
• Niflumic Acid
• Nilotinib
• Nimesulide
• Nimesulide Beta Cyclodextrin
• Norfloxacin
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Oxacillin
• Oxaprozin
• Oxyphenbutazone
• Paliperidone
• Panobinostat
• Parecoxib
• Paroxetine
• Pasireotide
• Pazopanib
• Penicillin G
• Penicillin G Benzathine
• Penicillin G Procaine
• Penicillin V
• Pentamidine
• Perflutren Lipid Microsphere
• Perphenazine
• Phenylbutazone
• Piketoprofen
• Pimavanserin
• Pipamperone
• Piperacillin
• Piroxicam
• Pitolisant
• Pivampicillin
• Posaconazole
• Probucol
• Procainamide
• Prochlorperazine
• Proglumetacin
• Promethazine
• Propafenone
• Propyphenazone
• Proquazone
• Protriptyline
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Rilpivirine
• Risperidone
• Ritonavir
• Rofecoxib
• Sertindole
• Sevoflurane
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sotalol
• Sulindac
• Sulpiride
• Sultamicillin
• Sunitinib
• Tacrolimus
• Tamoxifen
• Tegafur
• Telaprevir
• Telavancin
• Telithromycin
• Temocillin
• Tenoxicam
• Tetrabenazine
• Tiaprofenic Acid
• Tizanidine
• Tolfenamic Acid
• Tolmetin
• Tolterodine
• Toremifene
• Trazodone
• Tretinoin
• Trimipramine
• Triptorelin
• Valdecoxib
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voriconazole
• Vorinostat
• Warfarin
• Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aluminum Carbonate, Basic
• Aluminum Hydroxide
• Aluminum Phosphate
• Atovaquone
• Calcium
• Carbamazepine
• Cholestyramine
• Colestipol
• Cyclosporine
• Dihydroxyaluminum Aminoacetate
• Dihydroxyaluminum Sodium Carbonate
• Doxycycline
• Iron
• Lithium
• Magaldrate
• Magnesium Carbonate
• Magnesium Hydroxide
• Magnesium Oxide
• Magnesium Trisilicate
• Milk Thistle
• Probenecid
• Quinine
• Sulfinpyrazone
• Tamarind

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (blister card containing chewable tablets, tablets, and capsules):
  • For treatment of duodenal ulcers caused by H. pylori infection:
    • Adults—One dose (525 milligrams [mg] of bismuth subsalicylate, 250 mg of metronidazole, and 500 mg of tetracycline) four times a day, taken with meals and at bedtime, for 14 days.
    • Children—Use and dose must be determined by your doctor.

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss more than four doses of this combination of medicines, check with your doctor.