Cotrim
Name: Cotrim
- Cotrim side effects
- Cotrim dosage
- Cotrim dosage forms
- Cotrim tablet
- Cotrim drug
- Cotrim effects of
- Cotrim injection
- Cotrim weight loss
For the Consumer
Applies to sulfamethoxazole / trimethoprim: oral suspension, oral tablet
Other dosage forms:
- intravenous solution
Along with its needed effects, sulfamethoxazole/trimethoprim may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sulfamethoxazole / trimethoprim:
Rare- Abdominal or stomach pain
- black, tarry stools
- blistering, peeling, or loosening of the skin
- changes in skin color
- chest pain
- chills
- cough or hoarseness
- dark urine
- diarrhea
- dizziness
- fever with or without chills
- general feeling of tiredness or weakness
- headache
- itching
- joint or muscle pain
- light-colored stools
- loss of appetite
- lower back or side pain
- nausea
- pain, tenderness, or swelling of the foot or leg
- painful or difficult urination
- pale skin
- rash
- red skin lesions, often with a purple center
- red, irritated eyes
- shortness of breath
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- swollen or painful glands
- tightness in the chest
- unpleasant breath odor
- unusual bleeding or bruising
- vomiting of blood
- wheezing
- yellow eyes or skin
- Abdominal or stomach tenderness
- back, leg, or stomach pains
- bleeding gums
- blindness or vision changes
- blisters, hives, or itching
- bloating
- blood in the urine or stools
- bluish-colored lips, fingernails, or palms
- burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
- burning of the face or mouth
- chest pain
- cloudy urine
- confusion
- constipation
- continuing ringing or buzzing or other unexplained noise in the ears
- convulsions
- cracks in the skin
- decreased frequency or amount of urine
- diarrhea, watery and severe, which may also be bloody
- difficulty with breathing
- difficulty with swallowing
- fainting spells
- general body swelling
- general feeling of discomfort or illness
- hair loss
- hearing loss
- hives
- increased thirst
- indigestion
- irregular heartbeat
- large, flat, blue, or purplish patches in the skin
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of heat from the body
- muscle or joint pain
- nosebleeds
- not able to pass urine
- numbness or tingling in the hands, feet, or lips
- pain or burning while urinating
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- raised red swellings on the skin, the buttocks, legs, or ankles
- redness of the white part of the eyes
- redness, swelling, or soreness of the tongue
- sores, ulcers, or white spots on the lips or in the mouth
- soreness of the muscles
- stiff neck or back
- swelling of the face, hands, legs, and feet
- unsteadiness, trembling, or other problems with muscle control or coordination
- unusual weight loss
- weakness in the hands or feet
- weakness or heaviness of the legs
- weight gain
Some side effects of sulfamethoxazole / trimethoprim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common- Passing of gas
- Discouragement
- feeling of constant movement of self or surroundings
- feeling sad or empty
- increased sensitivity of the skin to sunlight
- irritability
- lack of feeling or emotion
- loss of interest or pleasure
- nervousness
- redness or other discoloration of the skin
- seeing, hearing, or feeling things that are not there
- sensation of spinning
- severe sunburn
- trouble concentrating
- trouble sleeping
- uncaring
- weight loss
For Healthcare Professionals
Applies to sulfamethoxazole / trimethoprim: intravenous solution, oral suspension, oral tablet
Cardiovascular
Rare (0.01% to 0.1%): Thrombophlebitis
Very rare (less than 0.01%): Polyarteritis nodosa, syncope
Postmarketing reports: QT prolongation resulting in ventricular tachycardia and torsade de pointes[Ref]
Dermatologic
Common (1% to 10%): Skin rash, urticaria
Very rare (less than 0.01%): Photosensitivity, exfoliative dermatitis, fixed drug eruption, erythema multiforme, erythema nodosum, Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis, bullous dermatitis, purpura, angioedema
Frequency not reported: Pruritus[Ref]
Gastrointestinal
Common (1% to 10%): Diarrhea, nausea, vomiting, anorexia
Very rare (less than 0.01%): Constipation, glossitis, stomatitis, pseudomembranous colitis, pancreatitis, abdominal pain
Frequency not reported: Sore mouth, moniliasis[Ref]
Hematologic
Very rare (less than 0.01%): Leucopenia, neutropenia, thrombocytopenia, pancytopenia, bone marrow depression, agranulocytosis, aplastic anemia, hemolytic anemia, eosinophilia, purpura, hemolysis
Frequency not reported: Megaloblastic anemia, methemoglobinemia, hypoprothrombinemia, granulocytopenia[Ref]
Hepatic
Rare (0.01% to 0.1%): Jaundice
Very rare (less than 0.01%): Hepatitis (including cholestatic jaundice and hepatic necrosis), disturbance in liver enzymes, elevated serum transaminases, elevated bilirubin[Ref]
Hypersensitivity
Very rare (less than 0.01%): Hypersensitivity, anaphylaxis, anaphylactoid reaction drug fever, chills, allergic vasculitis resembling Henoch-Schonlein purpura
Frequency not reported: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, conjunctival and scleral injection, photosensitivity, pruritus, urticaria, rash, periarteritis nodosa, systemic lupus erythematosus (SLE)[Ref]
Immunologic
Common (1% to 10%): Monilial overgrowth[Ref]
Local
Rare (less than 0.1%): Local reaction, pain, slight irritation[Ref]
Metabolic
Very common (10% or more): Hyperkalemia (particularly in the elderly and in HIV patients)
Very rare (less than 0.01%): Hypoglycemia, hyponatremia, metabolic acidosis[Ref]
Musculoskeletal
Rare (less than 0.1%): Rhabdomyolysis (mainly in AIDS patients)
Frequency not reported: Arthralgia, myalgia[Ref]
Nervous system
Very common (10% or more): Headache
Very rare (less than 0.01%): Aseptic meningitis (rapidly reversible on withdrawal of therapy but can reoccur on rechallenge), convulsions, peripheral neuritis, ataxia, vertigo, dizziness, tremor, lethargy, paresthesia, convulsions, peripheral neuritis, tinnitus[Ref]
Ocular
Very rare (less than 0.01%): Uveitis[Ref]
Psychiatric
Very rare (less than 0.01%): Depression, hallucination, confusional state, agitation, anxiety, abnormal behavior, insomnia, nightmares[Ref]
Renal
Very rare (less than 0.01%): Renal tubular acidosis, Impaired renal function (sometimes reported as renal failure), hematuria
Frequency not reported: Serum creatinine increased, blood urea nitrogen increased
Postmarketing reports:
Frequency not reported: Renal failure, interstitial nephritis, elevated BUN and serum creatinine, toxic nephrosis with oliguria and anuria, tubular necrosis, crystalluria, aggravation of renal disease, azotemia, hyperkalemic renal tubular acidosis, overestimations of normal creatinine values[Ref]
Respiratory
Very rare (less than 0.01%): Cough, dyspnea, lung infiltration, shortness of breath, wheezing, epistaxis[Ref]
For Healthcare Professionals
Applies to sulfamethoxazole / trimethoprim: intravenous solution, oral suspension, oral tablet
Cardiovascular
Rare (0.01% to 0.1%): Thrombophlebitis
Very rare (less than 0.01%): Polyarteritis nodosa, syncope
Postmarketing reports: QT prolongation resulting in ventricular tachycardia and torsade de pointes[Ref]
Dermatologic
Common (1% to 10%): Skin rash, urticaria
Very rare (less than 0.01%): Photosensitivity, exfoliative dermatitis, fixed drug eruption, erythema multiforme, erythema nodosum, Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis, bullous dermatitis, purpura, angioedema
Frequency not reported: Pruritus[Ref]
Gastrointestinal
Common (1% to 10%): Diarrhea, nausea, vomiting, anorexia
Very rare (less than 0.01%): Constipation, glossitis, stomatitis, pseudomembranous colitis, pancreatitis, abdominal pain
Frequency not reported: Sore mouth, moniliasis[Ref]
Hematologic
Very rare (less than 0.01%): Leucopenia, neutropenia, thrombocytopenia, pancytopenia, bone marrow depression, agranulocytosis, aplastic anemia, hemolytic anemia, eosinophilia, purpura, hemolysis
Frequency not reported: Megaloblastic anemia, methemoglobinemia, hypoprothrombinemia, granulocytopenia[Ref]
Hepatic
Rare (0.01% to 0.1%): Jaundice
Very rare (less than 0.01%): Hepatitis (including cholestatic jaundice and hepatic necrosis), disturbance in liver enzymes, elevated serum transaminases, elevated bilirubin[Ref]
Hypersensitivity
Very rare (less than 0.01%): Hypersensitivity, anaphylaxis, anaphylactoid reaction drug fever, chills, allergic vasculitis resembling Henoch-Schonlein purpura
Frequency not reported: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, conjunctival and scleral injection, photosensitivity, pruritus, urticaria, rash, periarteritis nodosa, systemic lupus erythematosus (SLE)[Ref]
Immunologic
Common (1% to 10%): Monilial overgrowth[Ref]
Local
Rare (less than 0.1%): Local reaction, pain, slight irritation[Ref]
Metabolic
Very common (10% or more): Hyperkalemia (particularly in the elderly and in HIV patients)
Very rare (less than 0.01%): Hypoglycemia, hyponatremia, metabolic acidosis[Ref]
Musculoskeletal
Rare (less than 0.1%): Rhabdomyolysis (mainly in AIDS patients)
Frequency not reported: Arthralgia, myalgia[Ref]
Nervous system
Very common (10% or more): Headache
Very rare (less than 0.01%): Aseptic meningitis (rapidly reversible on withdrawal of therapy but can reoccur on rechallenge), convulsions, peripheral neuritis, ataxia, vertigo, dizziness, tremor, lethargy, paresthesia, convulsions, peripheral neuritis, tinnitus[Ref]
Ocular
Very rare (less than 0.01%): Uveitis[Ref]
Psychiatric
Very rare (less than 0.01%): Depression, hallucination, confusional state, agitation, anxiety, abnormal behavior, insomnia, nightmares[Ref]
Renal
Very rare (less than 0.01%): Renal tubular acidosis, Impaired renal function (sometimes reported as renal failure), hematuria
Frequency not reported: Serum creatinine increased, blood urea nitrogen increased
Postmarketing reports:
Frequency not reported: Renal failure, interstitial nephritis, elevated BUN and serum creatinine, toxic nephrosis with oliguria and anuria, tubular necrosis, crystalluria, aggravation of renal disease, azotemia, hyperkalemic renal tubular acidosis, overestimations of normal creatinine values[Ref]
Respiratory
Very rare (less than 0.01%): Cough, dyspnea, lung infiltration, shortness of breath, wheezing, epistaxis[Ref]
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
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