Nafcillin injection

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include muscle spasms or twitching, confusion, seizure (black-out or convulsions).

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients (such as corn for products containing dextrose), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, kidney disease, liver disease.

This medication contains sodium. This could affect you if you are on a salt-restricted diet or if you have a condition which could be worsened with an increase in salt intake (e.g., congestive heart failure). Consult your doctor or pharmacist for more information.

Nafcillin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Liver and kidney functions decline as you grow older. This medication is removed by the liver. Therefore, elderly people may be at greater risk for side effects while using this drug.

Liver and kidney functions are not fully developed in newborns and infants. This medication is removed by the liver. Therefore, newborns and infants may be a greater risk for side effects while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast-feeding.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: seizures, confusion, mental/mood changes (e.g., agitation).

Notes

Laboratory and/or medical tests (e.g., kidney/liver function, complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.

Storage

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised November 2016. Copyright(c) 2016 First Databank, Inc.

2 g IV every 4 hours for 14 days depending on the nature and severity of the infection

The safety and efficacy of nafcillin when administered IV in neonates and children have not been established. However, the use of nafcillin IV may be appropriate in some situations.

0 to 4 weeks, birthweight 1199 g or less: 25 mg/kg IV or IM every 12 hours

7 days or less:
birthweight 1200 to 2000 g: 25 mg/kg IV or IM every 12 hours
birthweight 2001 g or more: 25 mg/kg IV or IM every 8 hours

8 days up to 1 month:
birthweight 1200 to 2000 g: 25 mg/kg IV or IM every 8 hours
birthweight 2001 g or more: 25 to 35 mg/kg IV or IM every 6 hours

1 month to 18 years:
Mild to moderate infections: 12.5 to 25 mg/kg IV or IM every 6 hours
Severe infections: 100 to 200 mg/kg/day IV in equally divided doses every 4 to 6 hours

Maximum dose: 12 g/day

The safety and efficacy of nafcillin when administered IV in neonates and children have not been established. However, the use of nafcillin IV may be appropriate in some situations.

0 to 4 weeks, birthweight 1199 g or less: 25 mg/kg IV or IM every 12 hours

7 days or less:
birthweight 1200 to 2000 g: 25 mg/kg IV or IM every 12 hours
birthweight 2001 g or more: 25 mg/kg IV or IM every 8 hours

8 days up to 1 month:
birthweight 1200 to 2000 g: 25 mg/kg IV or IM every 8 hours
birthweight 2001 g or more: 25 to 35 mg/kg IV or IM every 6 hours

1 month to 18 years:
Mild to moderate infections: 12.5 to 25 mg/kg IV or IM every 6 hours
Severe infections: 100 to 200 mg/kg/day IV in equally divided doses every 4 to 6 hours

Maximum dose: 12 g/day

There are no data on the excretion of nafcillin into human milk. Other penicillins are excreted into human milk in small amounts. Adverse effects in the nursing infant are unlikely. The manufacturer recommends that caution be used when administering nafcillin to nursing women.

Summary of Use during Lactation

Although no information is available on the use of nafcillin during breastfeeding, penicillins are generally not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with penicillins, but these effects have not been adequately evaluated. Nafcillin is acceptable to use during breastfeeding.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Dicloxacillin, Oxacillin, Methicillin

References

LactMed Record Number

193

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.