Dilaudid vs. Percocet

Hydromorphone is used for management of acute pain and moderate-to-severe chronic pain in patients when use of an opioid is appropriate.

Percocet is prescribed for the relief of moderate to moderately-severe pain.

Dilaudid Black Box Warning

BLACK BOX WARNING: Hydromorphone (generic name for Dilaudid)

• Dilaudid-HP Injection should not be confused with other types of Dilaudid injections or other opioids, as overdose and death could result.
• Avoid dosing errors from confusion between mg and mL when dispensing, prescribing, or administering the oral solution. Dosing errors can result in accidental overdose and death.
• Hydromorphone exposes patients to risks of addictions, abuse, and misuse, which can lead to overdose and death.
• Patients should be monitored closely because serious, life-threatening, or fatal respiratory depression may occur.
• Prolonged use of hydromorphone during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated. Pregnant woman should be advised of the risk of neonatal opioid withdrawal syndrome and appropriate treatment should be available.
• Combining opioids with benzodiazepines, alcohol, or other central nervous system (CNS) depressants may result in severe sedation, respiratory depression, coma, and death.

Dilaudid side effects

Common side effects

• Lightheadedness
• Dizziness
• Sedation
• Nausea
• Vomiting
• Constipation
• Sweating
• Flushing
• Itching
• Dry mouth

Other serious side effects:

• Other serious and important side effects of Dialudid are respiratory depression and trouble breathing.
• Since Dialudid is a controlled narcotic, it carries a box warning of respiratory depression and abuse potential. Use with alcohol or other medications affecting central nervous system can worsen respiratory depression and may lead to death.

Percocet side effects

The most frequent adverse reactions of Percocet (brand name for oxycodone/acetaminophen) include:

• Lightheadedness
• Dizziness
• Sedation
• Euphori
• Dysphoria
• Rash
• Itching
• Nausea
• Vomiting

Other important side effects include:

• Drowsiness
• Constipation
• Spasm of the ureter, which can lead to difficulty in urinating

Possible serious side effects include:

• Severe reduction in blood pressure (hypotension)
• Shock
• Seizures
• Paralytic ileus
• Serious allergic reactions
• Severe skin reactions

Percocet can depress breathing and, therefore, is used with caution in elderly, debilitated patients and in patients with serious lung disease. Percocet can impair thinking and the physical abilities required for driving or operating machinery.

Dilaudid drug interactions

• Dilaudid should be used very cautiously with medications that depress the central nervous system (for example, hypnotics, anesthetics, tranquilizers, phenothiazines, and alcohol).
• Dilaudid should be used with caution with mixed agonist/antagonist opioid analgesics (for example, pentazocine, nalbuphine, butorphanol, and buprenorphine) because it may take away the analgesic effect of hydromorphone.

Percocet drug interactions

• Oxycodone, like other narcotic pain-relievers, increases the effect of drugs that slow brain function, such as alcohol, barbiturates, skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines such as diazepam (Valium) and lorazepam (Ativan). Combined use of muscle relaxants or benzodiazepines and oxycodone may lead to increased respiratory depression.
• Since oxycodone causes constipation, the use of antidiarrheals, for example, diphenoxylate (Lomotil) and loperamide (Imodium), in persons taking oxycodone, can lead to severe constipation.
• Drugs which stimulate and also block opioid receptors, for example, pentazocine, nalbuphine (Nubain), butorphanol (Stadol), and buprenorphine (Subutex) may reduce the effect of oxycodone and may precipitate withdrawal symptoms.
• A fatty meal may increase the absorption of oxycodone by 27%.

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