Deoxycholic acid Kybella

Name: Deoxycholic acid Kybella

What is deoxycholic acid Kybella, and how does it work (mechanism of action)?

Deoxycholic acid (Kybella) is an injectable medication used for reducing fat in the submental region of the face (below the chin). Deoxycholic acid destroys the cell membrane of fat cells causing fat cells to die. Reducing the number of fat cells reduces fat under the chin. It should not be injected in other tissues because it also destroys other cells. In clinical studies 43% of people who received deoxycholic acid achieved a 10% reduction in submental fat volume after six or fewer treatment. Only 5% of people who received placebo achieved a 10% reduction in submental fat. Deoxycholic acid was approved by the FDA in April, 2015.

Is deoxycholic acid Kybella available as a generic drug?

GENERIC AVAILABLE: No

What are the side effects of deoxycholic acid Kybella?

Side effects of deoxycholic acid include:

  • injection site swelling,
  • edema,
  • pain,
  • numbness,
  • hematoma (collection of blood in tissues),
  • skin redness (erythema),
  • headache,
  • difficulty swallowing (dysphagia)
  • high blood pressure, and
  • nausea.

Injecting deoxycholic acid outside the submental area can cause damage to surrounding tissues. Injecting deoxycholic acid into the dermis may cause skin ulceration. Injecting deoxycholic acid into or in close proximity to the facial nerve may cause asymmetric smile and facial muscle weakness.

Is deoxycholic acid Kybella safe to take if I'm pregnant or breastfeeding?

There are no adequate studies of deoxycholic acid in pregnant women.

Deoxycholic acid has not been evaluated in nursing mothers.

What else should I know about deoxycholic acid Kybella?

What preparations of deoxycholic acid Kybella are available?

Injection: 10 mg/ml in 2 ml vials for single-patient use.

How should I keep deoxycholic acid Kybella stored?

Deoxycholic acid vials should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

Reviewed on 5/1/2015 References REFERENCE:

FDA Prescribing Information.
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