Copanlisib (Intravenous Route)

Appropriate studies have not been performed on the relationship of age to the effects of copanlisib injection in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of copanlisib injection in the elderly.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Diabetes or
• Hypertension (high blood pressure) or
• Infections (eg, pneumonia) or
• Lung or breathing problems or
• Neutropenia (blood problem)—Use with caution. May make these conditions worse.

• Infection—May decrease your body's ability to fight an infection.