Aprepitant (Intravenous Route)

Aprepitant injection is used together with other medicines (eg, dexamethasone, granisetron, ondansetron) to prevent acute and delayed nausea and vomiting caused by cancer medicines (chemotherapy). It is a substance P/neurokinin 1 (NK1) receptor antagonist that works by blocking the signals to the brain that cause nausea and vomiting.

This medicine is given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

• Emulsion

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Flibanserin
• Lomitapide
• Pimozide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acalabrutinib
• Atazanavir
• Boceprevir
• Bosutinib
• Brexpiprazole
• Carbamazepine
• Ceritinib
• Cilostazol
• Clarithromycin
• Cobicistat
• Cobimetinib
• Colchicine
• Conivaptan
• Deflazacort
• Desogestrel
• Dienogest
• Diltiazem
• Docetaxel
• Domperidone
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Dronedarone
• Drospirenone
• Enzalutamide
• Eplerenone
• Erythromycin
• Estradiol Cypionate
• Estradiol Valerate
• Ethinyl Estradiol
• Ethynodiol Diacetate
• Etonogestrel
• Fluconazole
• Fosphenytoin
• Hydrocodone
• Ibrutinib
• Idelalisib
• Imatinib
• Indinavir
• Itraconazole
• Ivabradine
• Ivacaftor
• Ketoconazole
• Letermovir
• Levonorgestrel
• Lopinavir
• Lumacaftor
• Lurasidone
• Medroxyprogesterone Acetate
• Mestranol
• Mitotane
• Naloxegol
• Nefazodone
• Nelfinavir
• Neratinib
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Olaparib
• Oxycodone
• Phenytoin
• Piperaquine
• Posaconazole
• Ranolazine
• Rifampin
• Ritonavir
• Saquinavir
• Simeprevir
• Sonidegib
• St John's Wort
• Tacrolimus
• Telaprevir
• Telithromycin
• Tolvaptan
• Venetoclax
• Verapamil
• Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Dexamethasone
• Methylprednisolone
• Midazolam
• Quetiapine
• Sirolimus
• Suvorexant
• Warfarin

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Liver disease, severe—Use with caution. May make this condition worse.