Sce-a

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Synthetic Conjugated Estrogens-A is a mixture of estrogen hormones used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

Synthetic Conjugated Estrogens-A should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

Synthetic Conjugated Estrogens-A may also be used for other purposes not listed in this medication guide.

Synthetic Conjugated Estrogens-A can cause birth defects in an unborn baby. Do not use Synthetic Conjugated Estrogens-A if you are pregnant. Do not use this medication if you have any of the following conditions: a history of heart attack, stroke, or blood clot (especially in your lung or your lower body), liver disease, abnormal vaginal bleeding, or a hormone-related cancer such as breast or uterine cancer.

Long-term treatment with conjugated estrogens may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using Synthetic Conjugated Estrogens-A long term, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Synthetic Conjugated Estrogens-A.

Synthetic Conjugated Estrogens-A should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

Use Synthetic Conjugated Estrogens-A exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

Synthetic Conjugated Estrogens-A are usually prescribed for only a short time and are most often used in a cycle, such as 3 weeks on followed by 1 week off. Some conditions require daily use and others require use only twice a week during the treatment period. Follow the directions on your prescription label.

To apply Synthetic Conjugated Estrogens-A, use only the vaginal applicator provided. After each use, take the applicator apart and clean it with mild soap and warm water. Do not use hot or boiling water.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis if you are using Synthetic Conjugated Estrogens-A long term.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using conjugated estrogens. You may need to stop using the medicine for a short time.

Synthetic Conjugated Estrogens-A can affect the results of certain medical tests. Tell any doctor who treats you that you are using conjugated estrogens.

Store this medication at room temperature away from moisture and heat.

Usual Adult Dose for Atrophic Vaginitis:

Treatment of Atrophic Vaginitis and Kraurosis Vulvae:

Conjugated estrogens topical synthetic A (Duramed): 1 gram intravaginally daily for one week followed by 1 gram intravaginally twice a week.

Before using conjugated estrogens, tell your doctor if you are using any of the following medicines:

• a blood thinner such as warfarin (Coumadin);

• a thyroid medication such as levothyroxine (Synthroid);

• insulin or diabetes medicine taken by mouth;

• rifampin (Rifadin, Rifater, Rifamate, Rimactane);

• ketoconazole (Nizoral) or itraconazole (Sporanox);

• seizure medicines such as phenytoin (Dilantin), carbamazepine (Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or primidone (Mysoline);

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or

• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

This list is not complete and there may be other drugs that can interact with Synthetic Conjugated Estrogens-A. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.