Alglucerase

Alglucerase is used in the treatment of:

• Liver Diseases
• Splenic Diseases

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Alglucerase may be found in some form under the following brand names:

• Ceredase

Alglucerase is available in the following forms:

• Injectable Solution

Frequency Not Defined

Discomfort, pruritus, burning, swelling, sterile abscess at venipuncture site

Mild fever

Chills

Abdominal discomfort

Nausea

Vomiting

Hypersensitivity symptoms during or shortly following infusion (eg, pruritus, flushing, urticaria, respiratory symptoms, nausea, abdominal cramping, hypotension)

Postmarketing Reports

Severe and serious infusion reactions including anaphylactic shock

Acute cardiorespiratory failure, possibly associated with fluid overload (in patients with pre-existing hypertrophic cardiomyopathy

Cardiac/respiratory arrest

Apnea

Stridor

Pharyngeal edema

Peripheral edema

Chest pain/discomfort

Muscle spasm

Fatigue

Conjunctivitis

Proteinuria and nephrotic syndrome

Systemic and cutaneous immune mediated reactions, including ulcerative and necrotizing skin lesions, and nephrotic syndrome secondary to membranous glomerulonephritis

Mechanism of Action

Catalyzes the hydrolysis of the glycolipid, glucocerebroside, to glucose and ceramide as part of the normal degradation pathway for membrane lipids; enzyme replacement for conditions with functional deficiency in beta-glucocerebrosidase enzymatic activity to prevent accumulation of lipid glucocerebroside

Pharmacokinetics

Half-Life: 3.6-10.4 minutes

Vd: 49.4-282.1 mL/kg

Clearance: Variable; 6.23-25.39 mL/min/kg