Radium-223 dichloride

>10%

Percentages includes all toxicity grades (1-4)

Anemia (93%)

Lymphocytopenia (72%)

Leukopenia (35%)

Thrombocytopenia (31%)

Nausea (36%)

Diarrhea (25%)

Vomiting (19%)

Neutropenia (18%)

Peripheral edema (13%)

1-10%

Percentages includes all toxicity grades (1-4)

Renal failure and impairment (3%)

Dehydration (3%)

Pancytopenia (2%)

Erythema, pain, and edema at injection site (1%)

Pregnancy Category: X

Lactation: Not indicated for women; unknown if distributed in human breast milk

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.