Nitric oxide gas

Mechanism of Action

Relaxes vascular smooth muscle, resulting in pulmonary vasodilation

Combines with oxyhemoglobin to produce methemoglobin & nitrate

Excretion

Nitrate excreted quickly, renal

Instructions

Must be adminstered using a calibrated INOmax DS-IR nitric oxide delivery system by trained personnel

Only validated ventilator systems should be used in conjunction with INOmax; consult the delivery system label or call 877-566-9466/visit inomax.com for a current list of validated systems

Keep available a back up battery power supply and an independent reserve nitric oxide delivery system to address power and system failures

Monitoring

Measure methemoglobin within 4-8 hr after initiating and periodically throughout treatment

Monitor for PaO2 and inspired NO2 during administration

Weaning & Discontinuation

Avoid abrupt discontinuation; wean gradually

To wean, downtitrate in several steps, pausing several hours at each step to monitor for hypoxemia