Fluticasone furoate inhaled

Contraindications

Status asthmaticus or other acute episodes of asthma

Hypersensitivity, including severe allergy to milk protein

Cautions

Localized infections of the mouth and pharynx with Candida albicans reported with inhaled corticosteroids

Not indicated for use as rescue therapy for acute bronchospasm (see Contraindications)

Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex; more serious or even fatal course of chickenpox or measles in susceptible patients; use caution because of potential for worsening of these infections; if exposed to chickenpox, prophylaxis with varicella-zoster immune globulin or pooled IV immunoglobulin may be indicated; if a patient is exposed to measles, prophylaxis with pooled IM immunoglobulin (IG) may be indicated

Caution when withdrawing from systemic corticosteroids and transferring to inhaled corticosteroids; taper systemic corticosteroids gradually and monitor for symptoms of HPA axis suppression and adrenal insufficiency

Systemic absorption from inhaled corticosteroids is low, but hypercorticism and adrenal suppression may occur with very high dosages or at regular dosage in susceptible individuals; if changes occur, discontinue therapy slowly

CYP3A4 substrate; strong CYP3A4 inhibitors may increase fluticasone systemic exposure

Paradoxical bronchospasm with immediate increase in wheezing after dosing reported; treat immediately with inhaled short-acting bronchodilator and discontinue fluticasone inhaled

Hypersensitivity reactions (eg, urticaria, flushing, allergic dermatitis, bronchospasm) reported; anaphylaxis in patients with severe milk protein allergy observed with other inhaled powder products that contain lactose

Long-term use decreases bone mineral density

May cause reduction in growth velocity when administered to children and adolescents

Glaucoma, increased intraocular pressure, and cataracts have been reported in patients following the long-term administration of inhaled corticosteroids

Epistaxis, nasal ulceration, Candida albicans infection, nasal septal perforation, impaired wound healing; monitor patients periodically for signs of adverse effects on nasal mucosa; avoid use in patients with recent nasal ulcers, nasal surgery, or nasal trauma