Pegademase
Name: Pegademase
Warnings
Contraindications
Use as a preparatory/support therapy for bone marrow transplantation
Severe thrombocytopenia
Cautions
Use caution in patients with thrombocytopenia; contraindicated in patients with severe thrombocytopenia
Monitor plasma ADA activity & red blood cell dATP levels
Development of antibodies reported, which may result in rapid clearance; adjust dose as necessary in patients developing antibodies
Risk for infection increases in patients that are not able to maintain adequate levels of plasma ADA
Not a substitute for bone marrow transplant
Pharmacology
Mechanism of Action
Replaces adenosing deaminase deficiency; the enzyme that catalyzes the deamination of deoxyadenosine and adenosine; this results in combined immunodeficiency disease with profound cellular and humoral immunity
Pharmacokinetics
Half-life: 3-6 days
Peak plasma time: 2-3 days
Absorption: Rapid
Patient Handout
Pegademase Drug Class
Pegademase is part of the drug class:
Other immunostimulants
Pegademase Interactions
This is not a complete list of Pegademasedrug interactions. Ask your doctor or pharmacist for more information.
Pegademase and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Pegademase falls into category C:
In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.
OR
There are no well-controlled studies that have been done in pregnant women. Pegademase should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.
OR
No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Pegademase should be given to a pregnant woman only if clearly needed.