Tripohist

Tripohist is part of the drug class:

• Other antihistamines for systemic use

Tripohist™ Liquid is an alcohol free, sugar free red syrup for oral administration having an apple odor and flavor.

Each teaspoonful (5 mL) contains:

Tripohist™ Liquid is contraindicated in individuals who have a known hypersensitivity to triprolidine HCl or any of its ingredients.

Do not exceed recommended dosage. If nervousness, dizziness, or sleeplessness occurs, discontinue use and consult a physician. If symptoms do not improve within 7 days or are accompanied by a fever, consult a physician. Do not take this product, unless directed by a physician, if you have a breathing problem such as emphysema or chronic bronchitis, or if you have glaucoma or difficulty in urination due to enlargement of the prostate gland. May cause drowsiness; alcohol, sedatives, and tranquilizers may increase the drowsiness effect. Avoid alcoholic beverages while taking this product. Do not take this product if you are taking sedatives or tranquilizers, without first consulting your physician. Use caution when driving a motor vehicle or operating machinery.

Antihistamines should be used with considerable caution in patients with glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, and bladder neck obstruction.

Pediatric Use

See PRECAUTIONS, Pediatric Use

This product may cause excitability especially in children.

Do not give this product to children who have a breathing problem such as chronic bronchitis, or who have glaucoma, without first consulting the child's physician.

This product may cause drowsiness. Sedatives and tranquilizers may increase the drowsiness effect. Do not give this product to children who are taking sedatives or tranquilizers, without first consulting the child's physician.

Drug Interactions

MAO inhibitors (or for 14 days after stopping MAOI therapy) and tricyclic antidepressants may prolong and intensify the anticholinergic (drying) effects of antihistamines. Concomitant use of antihistamines with tricyclic antidepressants, barbiturates, and other CNS depressants may have an additive effect. Antihistamines should be used with considerable caution in patients with history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease and hypertension.

Carcinogenesis, Mutagenesis, Impairment of Fertility

No adequate or well controlled studies have been conducted to determine whether the components of Tripohist™ Liquid have a potential for carcinogenesis, mutagenesis, or impairment of fertility.

Pregnancy

Animal reproduction studies have not been conducted with this product. It is not known whether it can cause fetal harm when administered to a pregnant women or can effect reproduction capacity. This product should not be administered to pregnant women.

Nursing Mothers

Due to the possible passage of the ingredients into breast milk, this product should not be given to nursing mothers.

Pediatric Use

Safety and effectiveness in the pediatric population, under 6, have not been established.

Signs and Symptoms

Manifestations of antihistamine overdosage may vary from CNS depression (sedation, apnea, cardiovascular collapse) to stimulation (insomnia, hallucinations, tremors or convulsions). Other signs and symptoms may be dizziness, tinnitus, blurred vision and hypotension. Stimulation is particularly likely in children, as are atropine-like signs and symptoms.

Treatment

Treatment of the signs and symptoms of overdosage is symptomatic and supportive. The patient should be induced to vomit, even if emesis has occurred spontaneously. Pharmacologic vomiting by the administration of ipecac syrup is a preferred method, however, vomiting should not be induced in patients with impaired consciousness. Precautions against aspiration must be taken, especially in infants and children. Following emesis, any drug remaining in the stomach may be absorbed by activated charcoal administered as a slurry with water.