Triprolidine Hydrochloride

Administration

Oral Administration

Administer orally as tablets or oral solution.101 102 103 104 a

Dosage

Available as triprolidine hydrochloride; dosage expressed in terms of the salt.101 102 103 104

Individualize dosage according to patient’s response and tolerance.a b

Fixed-combination preparations do not permit individual titration of dosages. When used in fixed combination with other agents (e.g., pseudoephedrine), select a dosage that is within the usual therapeutic range for each ingredient; dosage recommendations of triprolidine hydrochloride for adults and children when administered in fixed combinations are the same as when the drug is used as a single agent.a

Pediatric Patients

Allergic Conditions Allergic and Nonallergic Rhinitis, Allergic Conjunctivitis, and Allergic Skin Disorders Oral

Children 4 months to <2 years of age: 0.313 mg every 4–6 hours (as oral solution), not to exceed 1.252 mg in 24 hours.101 (See Pediatric Use Under Cautions.)

Children 2 to <4 years of age: 0.625 mg every 4–6 hours (as oral solution), not to exceed 2.5 mg in 24 hours.101

Children 4 to <6 years of age: 0.938 mg every 4–6 hours (as oral solution), not to exceed 3.75 mg in 24 hours.101

Allergic Rhinitis and Allergic Conjunctivitis

Self-medication in children 6 to <12 years of age: 1.25 mg every 4–6 hours (as tablets or oral solution), not to exceed 5 mg in 24 hours.103 104 105

Self-medication in children ≥12 years of age: 2.5 mg every 4–6 hours (as tablets or oral solution), not to exceed 10 mg in 24 hours.103 104 105

Common Cold Oral

Self-medication in children 6 to <12 years of age: 1.25 mg every 4–6 hours (as tablets or oral solution), not to exceed 5 mg in 24 hours.103 104

Self-medication in children ≥12 years of age: 2.5 mg every 4–6 hours (as tablets or oral solution), not to exceed 10 mg in 24 hours.103 104

Adults

Allergic Conditions Allergic Rhinitis and Allergic Conjunctivitis Oral

Self-medication: 2.5 mg every 4–6 hours (as tablets or oral solution), not to exceed 10 mg in 24 hours.103 104 105

Common Cold Oral

Self-medication: 2.5 mg every 4–6 hours (as tablets or oral solution), not to exceed 10 mg in 24 hours.103 104

Prescribing Limits

Pediatric Patients

Allergic Conditions Allergic and Nonallergic Rhinitis, Allergic Conjunctivitis, and Allergic Skin Disorders Oral

Children 4 months to <2 years of age: Maximum 1.252 mg in 24 hours.101

Children 2 to <4 years of age: Maximum 2.5 mg in 24 hours.101

Children 4 to <6 years of age: Maximum 3.75 mg in 24 hours.101

Allergic Rhinitis and Allergic Conjunctivitis

Self-medication in children 6 to <12 years of age: Maximum 5 mg in 24 hours.103 104 105

Self-medication in children ≥12 years of age: Maximum 10 mg in 24 hours.103 104 105

Common Cold Oral

Self-medication in children 6 to <12 years of age: Maximum 5 mg in 24 hours.103 104

Self-medication in children ≥12 years of age: Maximum 10 mg in 24 hours.103 104

Adults

Allergic Conditions Allergic Rhinitis and Allergic Conjunctivitis Oral

Self-medication: Maximum 10 mg in 24 hours.105

Common Cold Oral

Self-medication: Maximum 10 mg in 24 hours.103 104

Specific Drugs and Laboratory Tests

Drug or Laboratory Test	Interaction	Comments
CNS depressants (e.g., alcohol, hypnotics, sedatives, tranquilizers, tricyclic antidepressants)	Possible additive CNS depression101 102 105 b Tricyclic antidepressants prolong and intensify anticholinergic effects of antihistamines101	Avoid concomitant use102 105
MAO inhibitors	MAO inhibitors prolong and intensify anticholinergic effects of antihistamines101 102 b	Avoid use with or for 2 weeks after discontinuance of MAO inhibitors105
Test, antigen or histamine	Inhalation-challenge testing with histamine or antigen: Possible suppression of test response Antigen skin testing: Possible suppression of wheal and flare reactions

Absorption

Bioavailability

Rapidly absorbed.102

Therapeutic concentration achieved rapidly and usually maintained for 4–8 hours.102

Distribution

Extent

Distributed into milk.106 (See Lactation under Cautions.)

Elimination

Half-life

3–3.3 hours.101 102

Storage

Oral

Tablets

Tight, light-resistant containers at 15–30°C in a dry place.a

Solution

Tight, light-resistant containers at 15–30°C in a dry place;101 102 105 a do not freeze.a

• Blocks H1-receptor sites, thereby preventing the action of histamine on the cell.101 102 b

• Suppresses flare and pruritus that accompany the endogenous release of histamine.b

• Has anticholinergic and sedative effects.102

• Antihistamines do not block the stimulating effect of histamine on gastric acid secretion, which is mediated by H2-receptors of the parietal cells.b