Tobramcyin-ophthalmic drops

Tobramycin (Tobrex) is an antibiotic eye drop. Tobramycin is an aminoglycoside antibiotic that kills susceptible bacteria by blocking bacterial protein synthesis. Death of susceptible bacteria occurs because of the lack of functional proteins. Tobramycin treats only bacterial eye infections and does not work for other types of eye infections.

The FDA approved tobramycin eye drops in December 1980. In addition to eye drops, tobramycin is also available as 0.3% ointment which is also used to treat external bacterial infections of the eye.

For all patients ≥ 2 months of age: Instill 1-2 drops into the infected eye every 4 to 6 hours. For severe infections, instill 2 drops into the infected eye every 30 minutes to an hour until improvement and then reduce to less frequent dosing intervals as indicated. Patients using tobramycin ophthalmic solution:

• should wash their hands thoroughly with soap and water before and after using eye drops;
• should be advised not to wear contact lenses during treatment of active eye infections;
• must take care to avoid touching the dropper tip to the eye while administrating eye drops;
• should wait for at least 5 minutes between applications if other eye drop preparations also are used.

Most aminoglycoside antibiotics are excreted into breast milk in low concentrations. The risk for adverse effects in the nursing infant with use of ophthalmic tobramycin is considered to be low. However, consideration of the benefits of breastfeeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated infection should all be taken into account when making the decision to use tobramycin ophthalmic in nursing mothers.

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