Tpa

Name: TPA

What else should I know about alteplase (TPA, Activase, Cathflo Activase)?

What preparations of alteplase (TPA, Activase, Cathflo Activase) are available?

Powder is mixed with sterile water for injection: 2, 50, and 100 mg vials.

How should I keep alteplase (TPA, Activase, Cathflo Activase) stored?
  • The vials are stored at room temperature up to 80 F (30 C) or under refrigeration at 2-8 C (36-46 F).
  • Once mixed with sterile water, it must be used immediately.
  • Any drug not used must be thrown away.
How does alteplase (TPA, Activase, Cathflo Activase) work?
  • Alteplase is an enzyme that occurs naturally in man and causes blood clots to dissolve. It is a man-made protein manufactured by recombinant DNA technology. The naturally occurring protein, known as tissue plasminogen activator (TPA), is made by ovarian cells from the Chinese hamster. The amount that is given to patients is far greater than the amount naturally made by the body itself.
When was alteplase (TPA, Activase, Cathflo Activase) approved by the FDA?
  • Alteplase was first approved for heart attacks in 1987. In 1996, it was approved for strokes.
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