Trazodone-oral

Name: TRAZODONE-ORAL

TRAZODONE-ORAL missed dose
TRAZODONE-ORAL side effects
TRAZODONE-ORAL tablet
TRAZODONE-ORAL drug
TRAZODONE-ORAL effects of
TRAZODONE-ORAL the effects of
TRAZODONE-ORAL serious side effects
TRAZODONE-ORAL dosage
TRAZODONE-ORAL used to treat
TRAZODONE-ORAL injection
TRAZODONE-ORAL treats
TRAZODONE-ORAL adverse effects

Missed dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Before Using trazodone oral

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For trazodone oral, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to trazodone oral or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of trazodone oral in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of trazodone extended-release tablets in the elderly. However, elderly patients are more likely to have hyponatremia (low sodium in the blood), which may require caution in patients receiving trazodone oral.

No information is available on the relationship of age to the effects of trazodone regular tablets in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking trazodone oral, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using trazodone oral with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine
Amisulpride
Bepridil
Bromopride
Cisapride
Dronedarone
Fluconazole
Furazolidone
Iproniazid
Isocarboxazid
Ketoconazole
Linezolid
Mesoridazine
Methylene Blue
Metoclopramide
Moclobemide
Nelfinavir
Pargyline
Phenelzine
Pimozide
Piperaquine
Posaconazole
Procarbazine
Rasagiline
Safinamide
Saquinavir
Selegiline
Sparfloxacin
Terfenadine
Thioridazine
Tranylcypromine
Ziprasidone

Using trazodone oral with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alfentanil
Alfuzosin
Almotriptan
Amiodarone
Amitriptyline
Amoxapine
Amphetamine
Anagrelide
Apomorphine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Azithromycin
Benzphetamine
Brompheniramine
Buprenorphine
Buserelin
Buspirone
Butorphanol
Carbamazepine
Ceritinib
Chloroquine
Chlorpheniramine
Ciprofloxacin
Citalopram
Clarithromycin
Clomipramine
Clozapine
Cobicistat
Cocaine
Codeine
Conivaptan
Crizotinib
Cyclobenzaprine
Dabrafenib
Darunavir
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Desvenlafaxine
Deutetrabenazine
Dextroamphetamine
Dextromethorphan
Dihydrocodeine
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Droperidol
Duloxetine
Efavirenz
Eletriptan
Erythromycin
Escitalopram
Fenfluramine
Fentanyl
Fingolimod
Flecainide
Fluoxetine
Fluvoxamine
Foscarnet
Frovatriptan
Gatifloxacin
Gemifloxacin
Ginkgo
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Histrelin
Hydrocodone
Hydromorphone
Hydroxychloroquine
Hydroxytryptophan
Hydroxyzine
Ibutilide
Idelalisib
Iloperidone
Imipramine
Ivabradine
Lapatinib
Leuprolide
Levofloxacin
Levomilnacipran
Levorphanol
Lisdexamfetamine
Lithium
Lopinavir
Lorcaserin
Lumefantrine
Mefloquine
Methadone
Methamphetamine
Metronidazole
Mifepristone
Milnacipran
Mirtazapine
Morphine
Morphine Sulfate Liposome
Moxifloxacin
Nafarelin
Nalbuphine
Naratriptan
Nefazodone
Netupitant
Nilotinib
Norfloxacin
Nortriptyline
Octreotide
Ondansetron
Oxycodone
Oxymorphone
Paliperidone
Palonosetron
Panobinostat
Paroxetine
Pasireotide
Pazopanib
Pentazocine
Pimavanserin
Pitolisant
Procainamide
Propafenone
Propoxyphene
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Remifentanil
Ribociclib
Rizatriptan
Salmeterol
Sertraline
Sevoflurane
Sibutramine
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
St John's Wort
Sufentanil
Sulpiride
Sumatriptan
Sunitinib
Tacrolimus
Tapentadol
Telithromycin
Tetrabenazine
Toremifene
Tramadol
Trimipramine
Triptorelin
Tryptophan
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Vilazodone
Vinflunine
Voriconazole
Vortioxetine
Zolmitriptan
Zuclopenthixol

Using trazodone oral with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Atazanavir
Chlorpromazine
Digoxin
Fosphenytoin
Foxglove
Indinavir
Phenytoin
Ritonavir
Tipranavir
Trifluoperazine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Precautions

Before taking trazodone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood pressure problems, heart problems (such as irregular heartbeat, previous heart attack), kidney disease, liver disease, personal or family history of bipolar disorder, personal or family history of suicide attempts, personal or family history of glaucoma (angle-closure type).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

Trazodone may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using trazodone, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using trazodone safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Since untreated mental/mood problems (such as depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: digoxin.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

Other medications can affect the removal of trazodone from your body, which may affect how trazodone works. Examples include azole antifungals (such as itraconazole, ketoconazole), HIV drugs (such as ritonavir), macrolide antibiotics (such as erythromycin), rifamycins (such as rifampin), drugs used to treat seizures (such as phenytoin), among others.

The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Examples include street drugs such as MDMA/"ecstasy," St. John's wort, certain antidepressants (including SSRIs such as fluoxetine/paroxetine, SNRIs such as duloxetine/venlafaxine), tryptophan, among others. The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Important information

You should not use trazodone if you are allergic to it, or if you are being treated with methylene blue injection.

Do not use trazodone if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not give this medicine to anyone younger than 18 years old without the advice of a doctor. Trazodone is not approved for use in children.

What should I avoid while taking trazodone?

Do not drink alcohol. Trazodone can increase the effects of alcohol, which could be dangerous.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Trazodone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with this medicine may cause you to bruise or bleed easily.

What other drugs will affect trazodone?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking trazodone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with trazodone. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during your treatment, especially:

any other antidepressant;
anagrelide;
droperidol;
methadone;
ondansetron;
an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
cancer medicine--arsenic trioxide, vandetanib;
anti-malaria medication--chloroquine, halofantrine;
heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, pimozide, thioridazine.

This list is not complete and many other drugs can interact with trazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

In Summary

Commonly reported side effects of trazodone include: blurred vision, dizziness, drowsiness, headache, nausea, vomiting, and xerostomia. Other side effects include: syncope, edema, ataxia, confusion, diarrhea, hypotension, insomnia, sedation, and tachycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trazodone: oral tablet, oral tablet extended release

Along with its needed effects, trazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trazodone:

More common

Blurred vision
confusion
dizziness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
lightheadedness
sweating
unusual tiredness or weakness

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
confusion about identity, place, and time
decreased concentration
fainting
general feeling of discomfort or illness
headache
lack of coordination
muscle tremors
nervousness
pounding in the ears
shortness of breath
slow or fast heartbeat
swelling

Rare

Skin rash
unusual excitement

Some side effects of trazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: