Thiamilate

In the U.S.

• Thiamilate

Available Dosage Forms:

• Tablet
• Solution
• Capsule
• Tablet, Enteric Coated

Therapeutic Class: Nutritive Agent

Pharmacologic Class: Vitamin B (class)

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of thiamine than younger adults. Your health care professional may recommend that you take a vitamin supplement that contains thiamine.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this dietary supplement, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this dietary supplement with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Capecitabine
• Doxifluridine
• Fluorouracil
• Tegafur

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

10 to 20 mg IM three times daily for up to 2 weeks. Thereafter, use an oral therapeutic multivitamin preparation containing 5 to 10 mg thiamine daily for one month. A complete and balanced diet should follow.

Neuritis of pregnancy:
If vomiting severe to preclude oral therapy, give 5 to 10 mg IM daily.

'Wet' with myocardial failure:
Treat as an emergency cardiac condition. Thiamine is administered slowly by the IV route.

If dextrose administered: to patients with marginal thiamine status, give 100 mg in each of the first few liters of IV fluid to avoid precipitating heart failure.

50 to 100 mg orally once a day

10 to 25 mg IM or IV daily (if critically ill), or 10 to 50 mg orally every day for 2 weeks, then 5 to 10 mg orally daily for 1 month. If collapse occurs: 25 mg IV. Administer with caution.

If dextrose administered: to patients with marginal thiamine status, give 100 mg in each of the first few liters of IV fluid to avoid precipitating heart failure.

Data not available

Serious hypersensitivity/anaphylactic reactions have been reported, especially after repeated administration. A skin test should be performed on patients who are suspected of drug allergies or previous reactions to thiamine, and any positive responders should not receive thiamine by injection.

Deaths have been reported after the use of IV or IM administration of thiamine.

Thiamine injection contains aluminum. Toxic levels of aluminum may occur if prolonged parenteral administration is used in patients with kidney impairment.

Oral thiamine may be given with or without food.

Parenteral thiamine should be administered IM or by slow IV injection.

Dietary sources of thiamine include pork, beef, whole grains, yeast , fresh vegetables and legumes.

Recommended Dietary Allowances (RDA) in Adults:
Males: 1.2 mg daily
Female: 1.1 mg daily

Recommended Daily Allowance (RDA) in Pediatrics:
1 to 3 years: 0.5 mg/day
4 to 8 years: 0.6 mg/day
9 to 13 years: 0.9 mg/day

Males -14 to 18 years: 1.2 mg/day

Females - 14 to 18 years: 1.0 mg/day

Average Adequate Intake (AI) for healthy breast-fed infants:
0 to 6 months: 0.2 mg/day

7 to 12 months: 0.3 mg/day