Tofacitinib (Oral Route)

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tofacitinib in the elderly. However, elderly patients are more likely to have serious infections, which may require caution in patients receiving tofacitinib.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or
• Diabetes or
• Hyperlipidemia (high cholesterol in the blood) or
• Infection, history of or
• Stomach or bowel problems (eg, blockage, diverticulitis, perforation, ulcers), history of—Use with caution. May make these conditions worse.

• Hepatitis B, history of or
• Hepatitis C, history of or
• Herpes zoster infection or
• Tuberculosis, active or history of or
• Weakened immune system—May cause side effects to become worse.

• Infection, active or
• Liver disease, severe—Use is not recommended in patients with these conditions.

• Kidney disease, moderate or severe or
• Liver disease, moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.