Name: Tretin-X

Tretin-X Overview

Tretin-X is a prescription medication used to control acne. Tretin-X belongs to a group of drugs called retinoids. These work by promoting peeling of affected skin areas and unclogging pores. 

Tretinoin topical comes in a cream and gel forms and is applied to the face once a day.

Common side effects of Tretin-X include peeling, dry skin, and redness of the skin.


Uses of Tretin-X

Tretin-X is a prescription medication used to control acne, but does it cure acne.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Tretin-X Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Tretin-X Gel: store below 30°C (86°F).
  • Tretin-X Cream: store below 27°C (80°F).

Indications and Usage

TRETIN•X gel and cream are indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.


GELS ARE FLAMMABLE. AVOID FIRE, FLAME OR SMOKING DURING USE. Keep out of reach of children. Keep tube tightly closed. Do not expose to heat or store at temperatures above 120°F (49°C).


If medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling, or discomfort may occur. Oral ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.


NDC 14290-354-97


NDC 14290-352-97

Tretin-X (tretinoin topical) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using tretinoin topical and call your doctor at once if you have:

  • severe burning, stinging, or irritation of treated skin;

  • severe redness, swelling, blistering, peeling, or crusting;

Your skin may be more sensitive to weather extremes such as cold and wind while using this medicine.

Common side effects may include:

  • mild warmth or stinging where the medicine was applied; or

  • changes in color of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.