Trihexane

Trihexyphenidyl is a prescription medication used to treat tremors caused by Parkinson's disease, other conditions, or drugs.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Trihexane is part of the drug class:

• Tertiary amines

Trihexyphenidyl alters unusual nerve impulses and relaxes stiff muscles.

Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

Trihexyphenidyl may also be used for purposes other than those listed in this medication guide.

Take trihexyphenidyl exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Trihexyphenidyl may be taken with or without meals. Taking trihexyphenidyl with food may lessen stomach upset.

To ensure that you get a correct dose, measure the liquid form of trihexyphenidyl with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Store trihexyphenidyl at room temperature away from moisture and heat.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on the relationship of age to the effects of trihexyphenidyl in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of trihexyphenidyl in geriatric patients. However, elderly men are more likely to have age-related prostate problems, and all elderly patients are more likely to have age-related kidney, liver, or heart problems. These conditions may require caution or an adjustment in the dose for patients receiving trihexyphenidyl.

Breast Feeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Potassium

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Tiotropium

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Betel Nut
• Chlorpromazine
• Haloperidol
• Perphenazine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bowel or stomach blockage or
• Enlarged prostate or
• Glaucoma or
• Hypertension (high blood pressure) or
• Urinary blockage—Use with caution. May make these conditions worse.

• Kidney disease or
• Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.

This section provides information on the proper use of a number of products that contain trihexyphenidyl. It may not be specific to Trihexane. Please read with care.

Take this medicine every day exactly as ordered by your doctor in order to improve your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take this medicine before or after food, although it is usually taken with meals.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (elixir or tablets):
  • For Parkinson's disease:
    • Adults—At first, 1 milligram (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 15 mg per day, given in divided doses 3 or 4 times per day.
    • Children—Use and dose must be determined by your doctor.
  • For side effects caused by other medicines:
    • Adults—5 to 15 milligrams (mg) per day, given in divided doses 3 or 4 times per day.
    • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Abdominal or stomach cramps or pain
• bloating
• constipation
• delusions of persecution, mistrust, suspiciousness, or combativeness
• excessive dryness of the mouth
• false beliefs that cannot be changed by facts
• loss of appetite
• nausea or vomiting
• seeing, hearing, or feeling things that are not there
• skin rash
• stomach pain
• swollen, painful, or tender lymph glands on the side of the face or neck

• Anxiety
• blurred vision
• change in vision
• decrease in frequency of urination
• decrease in urine volume
• difficult urination
• difficulty in passing urine (dribbling)
• disturbed behavior
• dry mouth
• enlarged pupils
• eye pain
• fast, pounding, or irregular heartbeat or pulse
• hyperventilation
• irritability
• loss of vision
• mental confusion
• nervousness
• painful urination
• restlessness
• shaking
• shortness of breath
• trouble sleeping

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Dizziness
• mild nausea
• nervousness

• Drowsiness
• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Applies to trihexyphenidyl: oral capsule extended release, oral elixir, oral tablet

Along with its needed effects, trihexyphenidyl (the active ingredient contained in Trihexane) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trihexyphenidyl:

• Abdominal or stomach cramps or pain
• bloating
• constipation
• delusions of persecution, mistrust, suspiciousness, or combativeness
• excessive dryness of the mouth
• false beliefs that cannot be changed by facts
• loss of appetite
• nausea or vomiting
• seeing, hearing, or feeling things that are not there
• skin rash
• stomach pain
• swollen, painful, or tender lymph glands on the side of the face or neck

• Anxiety
• blurred vision
• change in vision
• decrease in frequency of urination
• decrease in urine volume
• difficult urination
• difficulty in passing urine (dribbling)
• disturbed behavior
• dry mouth
• enlarged pupils
• eye pain
• fast, pounding, or irregular heartbeat or pulse
• hyperventilation
• irritability
• loss of vision
• mental confusion
• nervousness
• painful urination
• restlessness
• shaking
• shortness of breath
• trouble sleeping

Some side effects of trihexyphenidyl may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Dizziness
• mild nausea
• nervousness

• Drowsiness
• weakness