Tezacaftor/Ivacaftor And Ivacaftor (Oral Route)

Tezacaftor/ivacaftor and ivacaftor combination is used to treat cystic fibrosis (CF) in patients 12 years of age and older. It is only used for patients who have two copies of F508del mutation, or who have at least one mutation in their CF transmembrane conductance regulator (CFTR) gene. Your doctor will use a test to check for the mutation before you receive the medicine.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Tablet

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies on the relationship of age to the effects of tezacaftor/ivacaftor and ivacaftor combination have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil
• Aprepitant
• Atazanavir
• Benzhydrocodone
• Boceprevir
• Buprenorphine
• Carbamazepine
• Ciprofloxacin
• Clarithromycin
• Cobicistat
• Codeine
• Conivaptan
• Crizotinib
• Cyclosporine
• Dihydrocodeine
• Diltiazem
• Dronedarone
• Duvelisib
• Eliglustat
• Enzalutamide
• Erythromycin
• Fentanyl
• Fluconazole
• Fluvoxamine
• Fosnetupitant
• Fosphenytoin
• Hydrocodone
• Idelalisib
• Imatinib
• Indinavir
• Itraconazole
• Ivosidenib
• Ketoconazole
• Letermovir
• Lopinavir
• Meperidine
• Methadone
• Mitotane
• Morphine
• Morphine Sulfate Liposome
• Nefazodone
• Nelfinavir
• Netupitant
• Nilotinib
• Oxycodone
• Pentazocine
• Phenytoin
• Posaconazole
• Rifampin
• Ritonavir
• Saquinavir
• St John's Wort
• Sufentanil
• Tacrolimus
• Telaprevir
• Telithromycin
• Tramadol
• Verapamil
• Voriconazole

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Grapefruit Juice

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.