Pegvaliase-Pqpz (Subcutaneous Route)

Name: Pegvaliase-Pqpz (Subcutaneous Route)

US Brand Name

  1. Palynziq


Pegvaliase-pqpz injection is used to lower phenylalanine levels in the blood in adults with phenylketonuria (PKU), who have uncontrolled blood phenylalanine levels with their current treatment.

This medicine is available only under a restricted distribution program called Palynziq™ REMS (Risk Evaluation and Mitigation Strategy) Program.

This product is available in the following dosage forms:

  • Solution


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form (solution):
    • For lowering phenylalanine levels in the blood:
      • Adults—The starting dose is usually 2.5 milligrams (mg) injected under the skin once a week for 4 weeks. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 40 mg injected under the skin once a day for 16 weeks.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

You may also keep this medicine at room temperature for up to 30 days. Do not return it to the refrigerator once you keep it at room temperature.

Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.