Tetanus and Diphtheria Vaccine

FREQUENCY OF ADMINISTRATION

More frequent administration of MassBiologics' Td than described in DOSAGE AND ADMINISTRATION may be associated with an increased incidence and severity of adverse reactions.

ARTHUS REACTIONS

Persons who experienced an Arthus-type hypersensitivity reaction following a prior dose of a tetanus toxoid-containing vaccine usually have high serum tetanus antitoxin levels and should not receive MassBiologics' Td more frequently than every 10 years, even for tetanus prophylaxis as part of wound management. (See DOSAGE AND ADMINISTRATION).

GUILLAIN-BARRÉ SYNDROME

A review by the Institute of Medicine found evidence for a causal relation between tetanus toxoid and Guillain-Barré Syndrome.9  If Guillain-Barré Syndrome occurred within 6 weeks after receipt of a previous dose of tetanus toxoid-containing vaccine, the decision to give subsequent doses of MassBiologics' Td or any vaccine containing tetanus toxoid should be based on careful consideration of the potential benefits and possible risks.10

Vaccination with MassBiologics' Td may not protect all individuals.