Tetracaine and Oxymetazoline

• Adrenergic Agonist Agent
• Imidazoline Derivative
• Local Anesthetic

Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer′s labeling (has not been studied); use with caution in patients with severe impairment.

For intranasal use only. Administer ipsilateral (same side) to the maxillary tooth on which the dental procedure will be performed. Wait 10 minutes following administration to perform a test drill to confirm that the tooth involved is anesthetized. Avoid use with other intranasal products, including other oxymetazoline-containing nasal sprays. Discontinue oxymetazoline-containing products 24 hours prior to administration of tetracaine/oxymetazoline.

Also see individual monographs.

>10%:

Ophthalmic: Increased lacrimation (13%)

Respiratory: Rhinorrhea (52%), nasal congestion (32%), nasal discomfort (26%), oropharyngeal pain (14%)

1% to 10%:

Cardiovascular: Increased systolic blood pressure (5%), bradycardia (3%), hypertension (3%), increased diastolic blood pressure (3%)

Central nervous system: Headache (10%), hypoesthesia (intranasal: 10%; pharyngeal: 10%), nasal cavity pain (6%), dizziness (3%), sensory disturbance (2%)

Gastrointestinal: Dysgeusia (8%), oral discomfort (2%), dysphagia (1%)

Respiratory: Throat irritation (9%), sneezing (4%), nasal mucosa ulcer (3%), sinus headache (3%), dry nose (2%), epistaxis (2%)

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience nosebleed, rhinorrhea, rhinitis, pharyngitis, throat pain, watery eyes, headache, or change in taste. Have patient report immediately to prescriber severe headache, dizziness, passing out, vision changes, difficulty swallowing, or signs of methemoglobinemia (blue or gray color of the lips, nails, or skin; abnormal heartbeat; seizures; severe dizziness or passing out; severe headache; fatigue; loss of strength and energy; or shortness of breath) (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients.