Terbutaline Sulfate

Name: Terbutaline Sulfate

Side effects

Adverse reactions observed with terbutaline are similar to those commonly seen with other sympathomimetic agents. All these reactions are transient in nature and usually do not require treatment.

The following table compares adverse reactions seen in patients treated with terbutaline sulfate injection (0.25 mg and 0.5 mg), with those seen in patients treated with epinephrine injection (0.25 mg and 0.5 mg), during eight double-blind crossover studies involving a total of 214 patients.

Incidence (%) of Adverse Reactions

  Terbutaline (%) Epinephrine (%)
0.25 mg 0.5 mg 0.25 mg 0.5 mg
N=77 N=205 N=153 N=61
Reaction  
Central Nervous System
  Tremor 7.8 38.0 16.3 18.0
  Nervousness 16.9 30.7 8.5 31.1
  Dizziness 1.3 10.2 7.8 3.3
  Headache 7.8 8.8 3.3 9.8
  Drowsiness 11.7 9.8 14.4 8.2
Cardiovascular
  Palpitations 7.8 22.9 7.8 29.5
  Tachycardia 1.3 1.5 2.6 0.0
Respiratory
  Dyspnea 0.0 2.0 2.0 0.0
  Chest discomfort 1.3 1.5 2.6 0.0
Gastrointestinal
  Nausea/vomiting 1.3 3.9 1.3 11.5
Systemic
  Weakness 1.3 0.5 2.6 1.6
  Flushed feeling 0.0 2.4 1.3 0.0
  Sweating 0.0 2.4 0.0 0.0
  Pain at injection site 2.6 0.5 2.6 1.6
Note: Some patients received more than one dosage strength of terbutaline sulfate and epinephrine. In addition, there were reports of anxiety, muscle cramps, and dry mouth ( < 0.5%). There have been rare reports of elevations in liver enzymes and of hypersensitivity vasculitis with terbutaline administration.

Stability

Storage

Oral

Tablets

Tight, light-resistant containers at 15–30°C.199

Parenteral

Solution for Injection

20–25°C.198 Protect from light by storing in original carton until use.198

Compatibility

For information on systemic interactions resulting from concomitant use, see Interactions.

Parenteral

Solution CompatibilityHID

Compatible

Dextrose 5% in water

Sodium chloride 0.45 or 0.9%
Drug Compatibility Admixture CompatibilityHID

Compatible

Aminophylline

Incompatible

Bleomycin sulfate
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