Synvisc-One

Hylan G-F 20 is injected directly into your knee joint. A healthcare provider will give you this injection.

Hylan G-F 20 is usually given once every week for 3 weeks. Follow your doctor's dosing instructions very carefully.

To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Call your doctor for instructions if you miss an appointment for your hylan G-F 20 injection.

Synvisc-One treats osteoarthritis (OA) of the knee in patients who have not found adequate response from physical therapy and pain relievers. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Serious side effects have been reported with Synvisc-One. See the “Synvisc-One Precautions” section.

Common side effects of Synvisc-One include the following in or around the knee:

• pain
• swelling
• heat
• redness
• fluid build-up

These reactions are generally mild and do not last long. Your doctor may recommend rest and applying ice to the injected knee.

This is not a complete list of Synvisc-One side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before receiving Synvisc-One, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

• are allergic to Synvisc-One or to any of its ingredients
• are allergic to products from birds, such as feathers, eggs, or poultry
• have an infection or skin disease in the area in which the injection is to be given
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

If Synvisc-One is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Hylan G-F 20 is injected directly into your knee joint. A healthcare provider will give you this injection.

The Synvisc brand of hylan G-F 20 is usually given once every week until you have received 3 injections. The Synvisc-One brand of this medicine is given only once. Your doctor will determine how many injections you should receive.

To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

Synvisc-One is a single-dose treatment that is injected directly into your knee. A healthcare provider will give you this injection.

To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

Usual Adult Dose for Osteoarthritis: Synvisc-One is administered as a single intra-articular injection. Strict aseptic administration technique must be followed.

• Inject the full 6 mL in one knee only.
• Using an 18 to 20 gauge needle, remove synovial fluid or effusion before injecting Synvisc-One.
• Do not use the same syringe for removing synovial fluid and for injecting Synvisc-One.
• Twist the tip cap before pulling it off, as this will minimize product leakage.
• To ensure a tight seal and prevent leakage during administration, secure the needle tightly while firmly holding the luer hub.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

There may be other drugs that can interact with Synvisc-One. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.