Taliglucerase alfa

Taliglucerase alfa is injected into a vein through an IV. A healthcare provider will give you this injection.

You may be given other medications to prevent certain side effects of taliglucerase alfa.

Taliglucerase alfa is usually given every other week. Follow your doctor's dosing instructions very carefully.

Your doctor may occasionally change your dose to make sure you get the best results.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Call your doctor for instructions if you miss an appointment for your taliglucerase alfa injection.

You should not use taliglucerase alfa if you are allergic to it.

FDA pregnancy category B. Taliglucerase alfa is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether taliglucerase alfa passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

No drug interactions have been reported by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Serious side effects have been reported with taliglucerase alfa including the following:

Allergic Reactions (Hypersensitivity reactions including anaphylaxis). Serious hypersensitivity or allergic reactions have occurred in some patients treated with taliglucerase alfa. Your doctor should monitor you for reactions before, during, and after you receive taliglucerase alfa. These reactions can occur up to 3 hours after receiving the infusion. Tell your doctor immediately if you experience any of the following signs or symptoms:

• hives (red itchy welts)
• low blood pressure
• wheezing
• chest tightness
• nausea or vomiting
• dizziness
• rash
• sudden cough
• irritated throat
• flushing (turning red in the face or other areas of the skin)

If you experience any of these symptoms, your doctor may slow your infusion or stop it altogether. Your doctor may give you certain medications before receiving taliglucerase alfa to help prevent any infusion reactions. 

Taliglucerase alfa can cause drowsiness. Do not drive or operate heavy machinery until you know how this medication affects you.

Do not receive taliglucerase alfa if you are allergic to taliglucerase alfa or to any of its ingredients.

Before receiving taliglucerase alfa, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

• are allergic to taliglucerase alfa or to any of its ingredients
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

(tal i GLOO ser ase AL fa)

• Elelyso

Note: Pretreatment with antihistamines and/or corticosteroids can be considered for prevention of subsequent infusion reactions in patients with an infusion reaction requiring symptomatic treatment; during clinical studies, patients were not routinely premedicated prior to infusion.

Gaucher disease (type 1): IV: 60 units/kg every 2 weeks; dosing is individualized based on disease severity.

Conversion from imiglucerase: Initiate taliglucerase alfa using the patient’s same previous imiglucerase dose and administer every 2 weeks. Note: Conversion to taliglucerase alfa is based on a single study of patients stabilized on a biweekly imiglucerase dose for ≥6 months

Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer’s labeling.