Patanol

Dosage Forms & Strengths

ophthalmic solution

• 0.1%
• 0.2%
• 0.7%

Allergic Conjunctivitis

Indicated for the treatment of ocular itching associated with allergic conjunctivitis

0.1% solution (Patanol): 1 gtt BID in affected eye(s) at an interval of 6-8 hr

0.2% solution (Pataday): 1 gtt in affected eye(s) qDay

0.7% (Pazeo): 1 gtt in affected eye(s) qDay

Dosage Forms & Strengths

ophthalmic solution

• 0.1%
• 0.2%
• 0.7%

Allergic Conjunctivitis

Indicated for the treatment of ocular itching associated with allergic conjunctivitis

<2 years (Pataday, Pazeo) or <3 years (Patanol): Safety and efficacy not established

0.1% solution (Patanol): 1-2 gtt BID in affected eye(s) at an interval of 6-8 hr

0.2% solution (Pataday): 1 gtt in affected eye(s) qDay

0.7% solution (Pazeo): 1 gtt in affected eye(s) qDay

Patanol is a prescription medication used to treat ocular (eye) itching associated with eye allergies.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Patanol eye drops can cause side effects including:

• headache
• blurred vision
• eye burning or stinging
• dry eyes
• swollen eye lids
• itching of the eye lids
• cold-like symptoms
• pharyngitis (sore throat)

Tell your doctor if any side effect is bothersome or does not go away.

This is not a complete list of Patanol side effects. Ask your doctor or pharmacist for more information.

Do not use Patanol if you are allergic to any ingredient in it.

Patanol Eye Drops

Do not wear contact lenses if your eyes are red. Patanol should not be used to treat contact lens-related irritation, or redness.

The preservative in Patanol, benzalkonium chloride, may be absorbed by soft contact lenses. Patients who wear soft contact lenses and whose eyes are not red should wait at least ten minutes after instilling Patanol before inserting contact lenses.

Do not allow dropper tip to contact your eye or any other surface.

Before using Patanol, tell your doctor:

• if you are allergic to Patanol or any other medicine
• if you are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

An overdose of olopatadine ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Contraindications

• Ophthalmic solution: Known hypersensitivity to olopatadine or any ingredient in the formulation.1

  Nasal spray: Manufacturer states none known.17

Warnings/Precautions

Proper Handling to Avoid Contamination of Ophthalmic Solution

To avoid contamination of the dropper tip and solution, do not to touch the eye, eyelids, or surrounding areas with the dropper tip.1 12 Close container tightly when not in use.1

Contact Lenses

Ophthalmic solution not indicated for contact lens-related ocular irritation.1 16 Do not wear contact lenses if eyes are red.1

Remove soft contact lenses prior to administration of each ophthalmic dose, since benzalkonium chloride preservative may be absorbed by soft contact lenses;12 16 lenses may be reinserted after ≥10 minutes following administration.1 16

Nasal Effects

Epistaxis, nasal ulcerations, and nasal septal perforations reported with nasal spray.17 Perform nasal examination prior to initiating intranasal olopatadine therapy to ensure absence of nasal diseases (other than allergic rhinitis).17 Perform nasal examinations periodically for signs of adverse effects on the nasal mucosa.17 If nasal ulcerations occur, consider discontinuing nasal spray.17

CNS Effects

Somnolence reported with nasal spray.17 Avoid engaging in activities requiring complete mental alertness and motor coordination (e.g., driving or operating machinery) after administration of nasal spray.17 Concomitant use of nasal spray with alcohol or other CNS depressants may result in additive CNS depression; therefore, avoid such concomitant use.17

Specific Populations

Category C.1

Distributed into milk in rats following oral administration.1

Ophthalmic solution: Not known whether distributed into human milk following topical application to the eye.1 Use with caution.1

Nasal spray: Use only if potential benefits outweigh risks.17

0.1% ophthalmic solution: Safety and efficacy not established in children <3 years of age.1 Appears to be well-tolerated in children 3–16 years of age.11 13

0.2% ophthalmic solution : Safety and efficacy not established in children <2 years of age.16

Nasal spray: Safety and efficacy not established in children <6 years of age.17 In clinical studies, incidence of epistaxis was higher in children 6–11 years of age (5.7%) compared with adolescents or adults (3.2%).17

Ophthalmic solution: No substantial differences in safety and efficacy relative to younger adults.1 16

Nasal spray: Insufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults.17 Other clinical experience has not identified differences in responses between geriatric and younger patients.17 Select dosage with caution because of age-related decreases in hepatic, renal, or cardiac function and potential for concomitant disease and drug therapy.17

Common Adverse Effects

0.1% ophthalmic solution: Headache.1 2 13

0.2% ophthalmic solution: Symptoms similar to cold syndrome, pharyngitis.16

Nasal spray: In adults and children ≥12 years of age, bitter taste, headache, epistaxis, pharyngolaryngeal pain, postnasal drip, cough, urinary tract infection.17 In children 6–11 years of age, epistaxis, headache, upper respiratory tract infection, bitter taste, pyrexia, rash.17

Olopatadine ophthalmic (eye) drops is used to treat itching of the eye caused by a condition known as allergic conjunctivitis (pink eye). It works by preventing the effects of certain inflammatory substances, which are produced by cells in your eyes and sometimes cause allergic reactions.

This medicine is available only with your doctor's prescription.

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• For the eye only.
• Wash your hands before and after use.
• Take out contact lenses before using Patanol. Talk with your doctor to see when lenses may be put back in after this medicine is given. Do not put contacts back in if your eyes are irritated or infected.
• Tilt your head back and drop drug into the eye.
• Do not touch the container tip to the eye, lid, or other skin.
• After use, keep your eyes closed. Put pressure on the inside corner of the eye. Do this for 1 to 2 minutes. This keeps the drug in your eye.

What do I do if I miss a dose?

• Use a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not use 2 doses or extra doses.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Store at room temperature.
• Keep lid tightly closed.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

Usual Adult Dose of Patanol for Seasonal Allergic Conjunctivitis:

Ophthalmic solution 0.1%: Instill one drop in each affected eye two times a day at a 6 to 8 hour interval.

Ophthalmic solution 0.2%: Instill one drop in each affected eye once a day.

Usual Pediatric Dose of Patanol for Seasonal Allergic Conjunctivitis:

2 years or younger: Safety and effectiveness have not been established.

3 to 18 years:
Ophthalmic 0.1% solution: Instill one drop in each affected eye two times a day at a 6 to 8 hour interval.
Ophthalmic 0.2% solution: Instill one drop in each affected eye once a day.

Applies to olopatadine ophthalmic: ophthalmic solution

Along with its needed effects, olopatadine ophthalmic (the active ingredient contained in Patanol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking olopatadine ophthalmic:

• Blurred vision
• eye irritation or pain
• swelling of the eyelid

Some side effects of olopatadine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Headache
• runny or stuffy nose
• sore throat

• Back pain
• body aches or pain
• burning, dryness, itching, or stinging of the eye
• change in taste
• chills
• cough
• diarrhea
• feeling of something in the eye
• general feeling of discomfort or illness
• increased cough
• lack or loss of strength
• loss of appetite
• muscle aches and pains
• nausea
• pain or tenderness around the eyes and cheekbones
• redness of the eye or inside of the eyelid
• sensitivity of the eyes to light
• shivering
• sneezing
• sweating
• tender, swollen glands in the neck
• trouble sleeping
• trouble swallowing
• unusual tiredness or weakness
• voice changes
• vomiting