Pentamidine (Injection Route)

Name: Pentamidine (Injection Route)

Pregnancy

Information about this pentamidine-injection-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Amisulpride
  • Bepridil
  • Cisapride
  • Dronedarone
  • Grepafloxacin
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Acetophenazine
  • Ajmaline
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Aprindine
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bretylium
  • Buserelin
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cidofovir
  • Citalopram
  • Clarithromycin
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Droperidol
  • Efavirenz
  • Encainide
  • Enflurane
  • Erythromycin
  • Escitalopram
  • Ethopropazine
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluphenazine
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Imipramine
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ketoconazole
  • Leuprolide
  • Levofloxacin
  • Lidoflazine
  • Lorcainide
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Methotrimeprazine
  • Metronidazole
  • Moxifloxacin
  • Nafarelin
  • Nilotinib
  • Nortriptyline
  • Octreotide
  • Ondansetron
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Perphenazine
  • Pimavanserin
  • Pipotiazine
  • Pirmenol
  • Pitolisant
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propafenone
  • Propiomazine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Risperidone
  • Sematilide
  • Sertindole
  • Sevoflurane
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Tacrolimus
  • Tedisamil
  • Telithromycin
  • Thiethylperazine
  • Tizanidine
  • Trifluoperazine
  • Triflupromazine
  • Trimeprazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vasopressin
  • Vemurafenib
  • Vinflunine
  • Zolmitriptan
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Zalcitabine

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Bleeding disorders (history of) or
  • Heart disease or
  • Hypotension (low blood pressure) or
  • Kidney disease or
  • Liver disease—Pentamidine may make these conditions worse
  • Diabetes mellitus (sugar diabetes) or
  • Hypoglycemia (low blood sugar)—Pentamidine may increase or decrease blood sugar levels and may disturb control of sugar diabetes

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For Pneumocystis carinii pneumonia (PCP):
      • Adults and children—Dose is based on body weight and must be determined by your doctor. The usual dose is 4 milligrams (mg) per kilogram (kg) (1.8 mg per pound) of body weight given once a day for fourteen to twenty-one days. This dose is injected slowly into a vein over a one- to two-hour period of time.
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