Pazopanib (Oral Route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of pazopanib in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pazopanib in the elderly. However, elderly patients are more likely to have unwanted effects (eg, decreased appetite, high blood pressure, tiredness) and age-related liver problems, which may require caution and an adjustment in the dose for patients receiving pazopanib.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (severe chest pain), history of or
• Blood clotting problems (eg, pulmonary embolism, venous thrombosis), history of or
• Congestive heart failure or
• Gilbert syndrome (a genetic liver disease) or
• Heart attack, history of or
• Heart disease or
• Heart rhythm problems (eg, QT prolongation), history of or
• Hypertension (high blood pressure) or
• Hypothyroidism (underactive thyroid) or
• Lung problems (eg, interstitial lung disease, pneumonitis) or
• Stomach or bowel problems (eg, fistula, perforation, tear), history of or
• Stroke, history of or
• Transient ischemic attack, history of—Use with caution. May make these conditions worse.

• Infection—May decrease your body's ability to fight an infection.

• Liver disease, moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose and it is less than 12 hours before your next scheduled dose, skip the missed dose and take your next dose at the normal time.