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Phentermine is a prescription medicine used to help adults lose weight.  It is taken for a limited amount of time by overweight people who are exercising and eating a low-calorie diet.

Phentermine can cause primary pulmonary hypertension, a rare but serious and sometimes fatal side effect. This is a condition where the pressure of the arteries in your lungs increases, causing more pressure on your heart which can lead to heart failure and death. The first symptoms is often shortness of breath or lightheadedness during activity. Other symptoms include:

• Ankle and leg swelling
• Bluish color of the lips or skin 
• Chest pain or pressure, usually in the front of the chest
• Dizziness or fainting spells
• Tiredness
• Increased abdomen size
• Weakness

Common side effects include:

• High blood pressure
• fast heart beats
• insomnia
• dizziness
• rash
• diarrhea
• tremors
• constipation

This is not a complete list of phentermine side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if phentermine crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using phentermine.

If you take too much phentermine, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

• Store phentermine at 20° to 25°C (68° to 77°F).
• Keep this and all medicines out of the reach of children.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of phentermine can be fatal.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• feeling short of breath, even with mild exertion;

• chest pain, feeling like you might pass out;

• swelling in your ankles or feet;

• pounding heartbeats or fluttering in your chest;

• confusion or irritability, unusual thoughts or behavior;

• feelings of extreme happiness or sadness; or

• dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).

Common side effects may include:

• feeling restless or hyperactive;

• headache, dizziness, tremors;

• sleep problems (insomnia);

• dry mouth or an unpleasant taste in your mouth;

• diarrhea or constipation, upset stomach; or

• increased or decreased interest in sex, impotence.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.