Oxymetazoline Topical

1-10%

Application-site dermatitis (2%)

Worsening inflammatory lesions of rosacea (1%)

Application-site pruritus (1%)

Application-site erythema (1%)

Application-site pain (1%)

Contraindications

None

Cautions

Alpha-adrenergic agonists may increase blood pressure; use caution with severe, unstable, or uncontrolled cardiovascular disease, orthostatic hypotension, or uncontrolled hypertension or hypotension; advise patients to seek immediate medical care if their condition worsens

Caution with cerebral or coronary insufficiency, Raynaud phenomenon, thromboangiitis obliterans, scleroderma, or Sjögren syndrome; advise patients to seek immediate medical care if signs and symptoms of vascular insufficiency develop

May increase risk of angle-closure glaucoma in patients with narrow-angle glaucoma; advise patients to seek immediate medical care if signs and symptoms of acute angle-closure glaucoma develop

Drug interaction overview

• Antihypertensives or cardiac glycosides: Alpha-adrenergic agonists, as a class, may increase blood pressure; caution with coadministration of beta-blockers, antihypertensives, and/or cardiac glycosides
• Monoamine oxidase (MAO) inhibitors: Caution is advised if coadministered with MAO inhibitors, which can affect the metabolism and uptake of circulating amines
• Other alpha1 adrenergic receptor agonists: Use caution in patients receiving alpha1 adrenergic receptor antagonists (eg, treatment of cardiovascular disease, benign prostatic hypertrophy, or Raynaud disease)

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Oxymetazoline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• inflammation of the skin
• itching
• worsening redness
• pain
• worsening of pimples

Oxymetazoline may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Irritation where this medicine is used.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Cream, External, as hydrochloride:

Rhofade: 1% (30 g) [contains cetostearyl alcohol, edetate disodium dihydrate, methylparaben, propylparaben]

Refer to adult dosing.

Store at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).

Avoid getting this medicine in your eyes or mouth.

Other drugs may interact with oxymetazoline topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.