Prestalia (as a combination product containing Amlodipine, Perindopril)

Before taking perindopril,

• tell your doctor and pharmacist if you are allergic to perindopril, angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), enalapril (Vasotec, in Vaseretic), fosinopril (Monopril), lisinopril (n Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), trandolapril (Mavik, in Tarka), any other medications, or any of the ingredients in perindopril tablets. Ask your pharmacist for a list of the ingredients.
• tell your doctor or pharmacist if you are taking valsartan and sacubitril (Entresto) or if you have stopped taking it within the last 36 hours. Your doctor will probably tell you not to take perindopril, if you are also taking valsartan and sacubitril. Also, tell your doctor if you have diabetes and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take perindopril if you have diabetes and you are also taking aliskiren.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: cyclosporine (Gengraf, Neoral, Sandimmune), diuretics ('water pills'), heparin, indomethacin (Indocin, Tivorbex), lithium (Lithobid), and potassium supplements (K-Dur, Klor-Con, others). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you are on dialysis and if have or have ever had heart failure; lupus (SLE); scleroderma; diabetes; angioedema (swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, and/or lower legs); or kidney or liver disease.
• tell your doctor if you are breastfeeding.
• you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting.

Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Perindopril may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• cough
• headache
• weakness
• dizziness
• diarrhea
• stomach pain
• upset stomach

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
• hoarseness
• difficulty swallowing or breathing
• lightheadedness
• fainting
• fever, sore throat, chills, and other signs of infection
• irregular or rapid heartbeats

Perindopril may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.