Magtrate

Magtrate is part of the drug class:

• Magnesium

• It is used to treat or prevent low magnesium levels.

• If you have an allergy to magnesium gluconate or any other part of Magtrate (magnesium gluconate tablets).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

• Tell all of your health care providers that you take Magtrate. This includes your doctors, nurses, pharmacists, and dentists.
• Have your blood work checked. Talk with your doctor.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Loose stools (diarrhea).

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Magtrate, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Magtrate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Magtrate.

Review Date: October 4, 2017

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Very upset stomach or throwing up.
• Very loose stools (diarrhea).

Applies to magnesium gluconate: compounding powder, oral liquid, oral tablet

Other

Other side effects have included effects from toxicity (hypermagnesemia). Mild hypermagnesemia is generally well-tolerated. Moderate or severe hypermagnesemia primarily affects the nervous and cardiovascular systems. The effects of hypermagnesemia may be worsened by the presence of hypocalcemia, especially in patients with uremia.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea. Magnesium toxicity has been associated with nausea (magnesium levels of 4 to 5 mEq/L) and rare cases of paralytic ileus (magnesium levels greater than 5 mEq/L).[Ref]

Nervous system

Nervous system side effects have resulted from the suppression of neuromuscular transmission in the CNS and at the neuromuscular junction by magnesium (antagonized by calcium). The degree of severity of these side effects has been dependent on the serum magnesium level. Clinically, if serum magnesium (Mg) levels increase to 4 to 7 mEq/L, there may be a decrease in tendon reflexes, muscle weakness and/or mental confusion/sedation. At levels of 7 to 10 mEq/L the respiratory rate slows and the blood pressure falls. At levels of 10 to 15 mEq/L there is usually profound mental depression, areflexia, coma and respiratory paralysis. Magnesium also has a curare-like effect at the neuromuscular junction at serum levels above 10 mEq/L. Death is not uncommon when serum magnesium levels rise to 15 mEq/L.[Ref]

Cardiovascular

The cardiovascular consequences of hypermagnesemia are due to peripheral vasodilation. Hypotension may be observed when serum magnesium levels rise to 7 to 10 mEq/L, becoming severe when serum magnesium levels rise above 10 mEq/L. Magnesium can also depress myocardial conductivity and cause bradyarrhythmias at levels greater than 10 mEq/L. While some patients are inexplicably able to tolerate extraordinary magnesium levels, there is a significant risk of asystole when levels rise to 25 mEq/L. The risk of cardiotoxicity from hypermagnesemia is increased in the presence of hypocalcemia, hyperkalemia, acidosis, digitalis therapy, and renal insufficiency.[Ref]

Cardiovascular side effects have included hypotension, depressed myocardial conductivity, and bradyarrhythmias.[Ref]

Metabolic

Acute hypermagnesemia may cause hypocalcemia due to suppression of the release of parathyroid hormone (PTH) and competition for renal tubular reabsorption between calcium (Ca) and magnesium. The latter can lead to decreased Ca reabsorption and hypercalciuria, which aggravates the hypocalcemia produced by decreased release of PTH.[Ref]

Metabolic side effects have included hypocalcemia.[Ref]

General

Magnesium (Mg) gluconate is generally well-tolerated.[Ref]

Some side effects of Magtrate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.