Marcaine HCl

Name: Marcaine HCl

Commonly used brand name(s)

In the U.S.

  • Marcaine HCl
  • Marcaine Spinal
  • Sensorcaine
  • Sensorcaine-MPF

Available Dosage Forms:

  • Solution
  • Kit
  • Injectable

Therapeutic Class: Anesthetic, Local

Chemical Class: Bupivacaine

Uses For Marcaine HCl

Bupivacaine injection is used to numb an area of your body during surgery or other procedures, childbirth, or dental work. It is a local anesthetic.

Bupivacaine injection causes a loss of feeling and prevents pain by blocking signals at the nerve endings. It does not cause a loss of consciousness.

This medicine is to be given only by or under the direct supervision of your doctor.

Before Using Marcaine HCl

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of bupivacaine injection in the pediatric population. Use is not recommended in children. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bupivacaine injection in the elderly. However, elderly patients are more likely to have low blood pressure or kidney problems, which may require caution and an adjustment in the dose for patients receiving bupivacaine injection.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Bupropion
  • Donepezil
  • Fospropofol
  • Hyaluronidase
  • Propofol
  • Propranolol
  • St John's Wort
  • Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alacepril
  • Benazepril
  • Captopril
  • Cilazapril
  • Delapril
  • Enalaprilat
  • Enalapril Maleate
  • Fosinopril
  • Imidapril
  • Lisinopril
  • Moexipril
  • Pentopril
  • Perindopril
  • Quinapril
  • Ramipril
  • Spirapril
  • Temocapril
  • Trandolapril
  • Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Arthritis or
  • Back pain, chronic or
  • Blood clotting problems or
  • Headache, before surgery or
  • Mental illness (eg, psychosis) or
  • Paresthesia (nerve problem), persistent or
  • Pernicious anemia, history of or
  • Poliomyelitis, history of or
  • Spinal problems or
  • Syphilis, history of or
  • Tumor, history of—Use with caution. May prevent the use of bupivacaine in patients with these conditions.
  • Heart rhythm problems (eg, arrhythmia, heart block) or
  • Hemorrhage (bleeding), severe or
  • Hypotension (low blood pressure), severe or
  • Infection at the injection site or
  • Septicemia (blood infection) or
  • During uterine contractions —Should not be used in patients with these conditions.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of bupivacaine

This section provides information on the proper use of a number of products that contain bupivacaine. It may not be specific to Marcaine HCl. Please read with care.

A nurse or other trained health professional will give you this medicine in a hospital. It is sometimes given through a catheter placed into your lower back for an epidural or a spinal block.

This medicine should cause numbness only to the area where it is injected. You may experience temporary loss of sensation or movement in the injected area. This type of numbing procedure is called local anesthesia. It is not meant to cause you to fall asleep or become unconscious.

It may be easier to hurt yourself while your treated body area is still numb. Be careful to avoid injury until you have regained all the feeling and are no longer numb.

If you are receiving this medicine as an epidural to ease labor pains, it may take longer than normal for you to push your baby out. It is also possible that the baby may have unwanted effects after birth (including sleepiness, slow responses). Talk to your doctor if you have questions about how this medicine might affect your baby.

Precautions While Using Marcaine HCl

It is very important that your doctor check your progress closely after you receive this medicine to see if it is working properly and to check for any unwanted effects.

This medicine may cause a bone or joint problem called chondrolysis. Check with your doctor right away if you have bone or joint pain or stiffness or an inability to move.

This medicine may cause low blood pressure (hypotension). This is more likely in patients with blood vessel problems, including high blood pressure (hypertension) or a decrease in blood volume. Check with your doctor right away if you have confusion, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, sweating, or unusual tiredness or weakness.

Bupivacaine injection may also cause a dangerous increase in body temperature (hyperthermia). Check with your doctor if you have fast shallow breathing, a fast, weak heartbeat, headache, muscle cramps, pale, clammy skin, or an extremely high fever or body temperature.

This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Check with your doctor before receiving this medicine with other medicines that affect the central nervous system (CNS). The use of other medicines that affect the CNS with bupivacaine injection may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, or muscle relaxants.

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