GlucaGen Diagnostic

• If you have an allergy to GlucaGen Diagnostic (glucagon (diagnostic aid)) or any part of this medicine.
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have an adrenal gland tumor called pheochromocytoma.
• If you have certain types of pancreas tumors (glucagonoma, insulinoma).
• If you take other drugs called anticholinergics, like ipratropium or oxybutynin. Ask your doctor if you are not sure if any of your drugs are anticholinergic.

This is not a list of all drugs or health problems that interact with GlucaGen Diagnostic.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

• Tell all of your health care providers that you take GlucaGen Diagnostic. This includes your doctors, nurses, pharmacists, and dentists.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
• Avoid driving and doing other tasks or actions that call for you to be alert until you eat a meal.
• High or low blood sugar may happen in some patients after GlucaGen Diagnostic is given. Talk with the doctor.
• You will be watched closely by your doctor.
• This medicine is not approved for use in children. Talk with the doctor.

Applies to glucagon: injectable powder for injection

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting. A higher incidence of nausea and vomiting has been reported with higher doses.[Ref]

Endocrine

Endocrine side effects have included symptoms of hypoglycemia following a dose of glucagon.[Ref]

Hypersensitivity

Hypersensitivity side effects have included generalized allergic reactions, including urticaria, respiratory distress, and hypotension.[Ref]

Some side effects of glucagon may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Less than 20 kg: 0.5 mg (0.5 unit) subcutaneous, IM or IV.

20 kg or more: 1 mg (1 unit) subcutaneous, IM or IV.

Neonates:
0.02 to 0.2 mg/kg subcutaneous, IM, or IV (maximum dose: 1 mg); Note: Wide variance in doses exists between manufacturers labeling and published case reports.
Neonates: continuous IV infusion: 1 mg infused over 24 hours; doses greater than 0.02 mg/kg/hour did not produce additional benefit.
Children:
Less than 20 Kg: 0.5 mg (0.5 unit) or a dose equivalent to 20 to 30 mcg/Kg.
20 Kg or more : 1 mg (1 unit) subcutaneous, IM, or IV

0.5 mg (0.5 units) IV or 2 mg (2 units) IM are recommended for examinations of the stomach since it is less sensitive to the effects of glucagon.

Dose and route of administration may vary depending on the onset of action and approximate duration of effect required for the examination. Doses of 0.25 to 0.5 mg (0.25 to 0.5 units) and 2 mg (2 units) administered IV reached an onset of action in 1 minute with a duration of effect lasting 9 to 17 minutes and 22 to 25 minutes, respectively. Doses of 1 mg IM reached an onset of action in 8 to 10 minutes with a duration of effect lasting 12 to 27 minutes. A dose of 2 mg (2 units) IM reached an onset of action in 4 to 7 minutes with a duration of effect lasting 21 to 32 minutes.