Glycine

Glycine may be found in some form under the following brand names:

• Aminosyn 10%, Sulfite-Free

• Aminosyn 3.5 % M, Sulfite Free

• Aminosyn 3.5%, Sulfite-Free

• Aminosyn 5%, Sulfite-Free

• Aminosyn 7 % with Electrolytes, Sulfite-Free

• Aminosyn 7%, Sulfite-Free

• Aminosyn 8.5 % with Electrolytes, Sulfite-Free

• Aminosyn 8.5%, Sulfite-Free

• Aminosyn II 10 %

• Aminosyn II 15%

• Aminosyn II 3.5 % in 25 % Dextrose

• Aminosyn II 3.5 % M in 5 % Dextrose

• Aminosyn II 3.5 % with Electrolytes in 25 % Dextrose with Calcium

• Aminosyn II 3.5% in 5% Dextrose

• Aminosyn II 4.25 % with Electrolytes in 25 % Dextrose with Calcium

• Aminosyn II 4.25% in 10% Dextrose

• Aminosyn II 4.25% in 20% Dextrose

• Aminosyn II 4.25/25

• Aminosyn II 5% in 25% Dextrose

• Aminosyn II 7 %, Sulfite-Free

• Aminosyn II 8.5 % with Electrolytes, Sulfite-Free

• Aminosyn II 8.5 %, Sulfite-Free

• Aminosyn-HBC 7 %, Sulfite-Free

• Aminosyn-HF 8 %

• Aminosyn-PF 10 %, Sulfite-Free

• Aminosyn-PF 7%

• Clinimix 2.75/5

• Clinimix 4.25/10

• Clinimix 4.25/20

• Clinimix 4.25/25

• Clinimix 4.25/5

• Clinimix 5/15

• Clinimix 5/20

• Clinimix 5/25

• Clinimix E 2.75/10

• Clinimix E 2.75/5

• Clinimix E 4.25/10

• Clinimix E 4.25/25

• Clinimix E 4.25/5

• Clinimix E 5/15

• Clinimix E 5/20

• Clinimix E 5/25

• Clinimix E 5/35

• Clinisol 15

• FreAmine 6.9

• Freamine III 10

• Freamine III 3

• Freamine III 8.5

• Hepatamine 8

• Hepatasol

• Novamine 15%

• PremaSol

• ProcalAmine 3

• Prosol

• Renamin 6.5

• Travasol 10%

• Travasol 2.75

• Travasol 2.75/5

• Travasol 3.5

• Travasol 4.25/10

• Travasol 4.25/25

• Travasol 4.25/5

• Travasol 5.5 % in Dextrose

• Travasol 8.5 Electrolytes

• Trophamine

• Trophamine 10 %

• Trophamine 6 %

Glycine is part of the drug class:

• Other irrigating solutions

This is not a complete list of Glycinedrug interactions. Ask your doctor or pharmacist for more information.

1.5% Glycine Irrigation, USP is a sterile, nonpyrogenic, hypotonic, aqueous solution of Glycine intended only for urologic irrigation during transurethral surgical procedures.

Each 100 mL contains 1.5 g of Glycine in water for injection. The solution is nonelectrolytic, hypotonic and has an osmolarity of 200 mOsmol/liter (calc.); pH 6.0 (4.5 to 6.5).

The solution contains no bacteriostat, antimicrobial agent or added buffer and is intended only for use as a single-dose irrigation. When smaller volumes are required, the unused portion should be discarded.

1.5% Glycine Irrigation is a urologic nonelectrolyte irrigant.

Glycine, USP is chemically designated aminoacetic acid (C2H5NO2), a white crystalline powder freely soluble in water. It has the following structural formula:

NH2CH2COOH

Water for Injection, USP is chemically designated H20.

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.

The semi-rigid container is fabricated from a specially formulated polyolefin. It is a copolymer of ethylene and propylene. The container requires no vapor barrier to maintain the proper drug concentration.

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

Glycine is an amino acid and a nonelectrolyte. A solution of Glycine in water is therefore nonconductive and suitable for urologic irrigation during electrosurgical procedures. A 1.5% concentration of Glycine in water (200 mOsmol/liter calc.) is sufficient to minimize the risk of intravascular hemolysis which can occur from absorption of plain water through open prostatic veins during transurethral resection (TUR). It is hypotonic in relation to the extracellular fluid (280 mOsmol/liter). Any solution absorbed intravascularly during transurethral prostatic or bladder surgery, although variable in amount depending primarily on the extent of surgery, will be excreted by the kidney. Studies have shown that the absorption of Glycine does not cause significant hemolysis (increase of free hemoglobin) or release significant amounts of free ammonia in the blood. Glycine is rapidly degraded in the liver by Glycine oxidase.

Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production).

Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium.

2
HDPE

TO OPEN TEAR AT NOTCH

DO NOT REMOVE FROM OVERWRAP UNTIL READY FOR USE. AFTER REMOVING
THE OVERWRAP, CHECK FOR MINUTE LEAKS BY SQUEEZING CONTAINER FIRMLY.
IF LEAKS ARE FOUND, DISCARD SOLUTION AS STERILITY MAY BE IMPAIRED.
RECOMMENDED STORAGE: ROOM TEMPERATURE (25°C). AVOID EXCESSIVE
HEAT. PROTECT FROM FREEZING. SEE INSERT.
98-4321-R14-3/98

Consult your pharmacist.

How to use Glycine Powder

Consult your pharmacist.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Missed Dose

Consult your pharmacist.

Storage

Consult your pharmacist.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.