Glycopyrrolate

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Glycopyrrolate is a medicine used to treat ulcers and reduce excessive drooling caused by certain medical conditions (especially cerebral palsy).

The medicine is sold under the brand names Robinul, Cuvposa, Robinul Forte, and Glycate.

Glycopyrrolate is also given before surgery to reduce secretions in the mouth, throat, airways, and stomach — and it's given both before and during surgery to block certain reflexes and protect against side effects of some medications.

Glycopyrrolate belongs to a class of drugs called anticholinergics. It works by blocking the activity of acetylcholine, a neurotransmitter.

The Food and Drug Administration (FDA) first approved glycopyrrolate in 1961. It's manufactured by several different pharmaceutical companies.

Glycopyrrolate Warnings

Before taking glycopyrrolate, tell your doctor if you have, or have ever had:

• Glaucoma
• An enlarged prostate
• Ulcerative colitis
• Paralytic ileus (a bowel condition)
• Gastrointestinal disease
• Myasthenia gravis (a chronic neuromuscular disease)
• Overactive thyroid
• High blood pressure
• Irregular or rapid heartbeat
• Heart failure or coronary artery disease
• Hiatal hernia (a condition in which part of the stomach pushes up into the chest) with reflux
• Kidney or liver disease
• Disorders of the nervous system
• Spastic paralysis (a disorder characterized by weakness and stiffness of muscles) or brain damage
• Allergies to medicines

Tell your doctor you take glycopyrrolate before having any type of surgery, including a dental procedure.

Glycopyrrolate may reduce your body's ability to cool down by sweating. It can cause fever or heat stroke in very high temperatures.

Be sure to drink plenty of water and avoid excessive heat while taking this medicine.

Glycopyrrolate can also make your eyes more sensitive to sunlight, so it may be helpful to wear sunglasses while taking the medication.

Elderly people and children may be more sensitive to certain side effects of glycopyrrolate. Talk to your doctor if this is a concern.

Newborns and infants should not take glycopyrrolate unless a doctor tells you otherwise.

Some formulations of the drug contain benzyl alcohol, which can cause serious and sometimes fatal side effects in babies.

Pregnancy and Glycopyrrolate

Talk to your doctor if you're pregnant or become pregnant while taking glycopyrrolate.

You'll have to discuss the risks and benefits of using this medicine during pregnancy.

It's not known whether glycopyrrolate passes into breast milk. Check with your doctor before breastfeeding while taking this drug.

Anticholinergics, including ROBINUL Injection, can produce certain effects, most of which are extensions of their pharmacologic actions. Adverse reactions may include xerostomia (dry mouth); urinary hesitancy and retention; blurred vision and photophobia due to mydriasis (dilation of the pupil); cycloplegia; increased ocular tension; tachycardia; palpitation; decreased sweating; loss of taste; headache; nervousness; drowsiness; weakness; dizziness; insomnia; nausea; vomiting; impotence; suppression of lactation; constipation; bloated feeling; severe allergic reactions including anaphylactic/anaphylactoid reactions; hypersensitivity; urticaria, pruritus, dry skin, and other dermal manifestations; some degree of mental confusion and/or excitement, especially in elderly persons.

In addition, the following adverse events have been reported from post-marketing experience with ROBINUL: malignant hyperthermia; cardiac arrhythmias (including bradycardia, ventricular tachycardia, ventricular fibrillation); cardiac arrest; hypertension; hypotension; seizures; and respiratory arrest. Postmarketing reports have included cases of heart block and QTc interval prolongation associated with the combined use of glycopyrrolate and an anticholinesterase. Injection site reactions including pruritus, edema, erythema, and pain have also been reported.

ROBINUL is chemically a quaternary ammonium compound; hence, its passage across lipid membranes, such as the blood-brain barrier is limited in contrast to atropine sulfate and scopolamine hydrobromide. For this reason the occurrence of CNS-related side effects is lower, in comparison to their incidence following administration of anticholinergics which are chemically tertiary amines that can cross this barrier readily.

Glycopyrrolate may be found in some form under the following brand names:

• Cuvposa

• Robinul

• Seebri Neohaler

Your pharmacist can provide more information about glycopyrrolate.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 3.02. Revision date: 10/3/2011.

Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include weak or shallow breathing, feeling cold, jerky muscle movements, or seizure (convulsions).

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using glycopyrrolate and call your doctor at once if you have a serious side effect such as:

• severe constipation, severe stomach pain and bloating;

• diarrhea (especially if you have a colostomy or ileostomy);

• feeling like you might pass out;

• feeling very thirsty or hot, being unable to urinate, heavy sweating, weak pulse, or hot and dry skin; or

• dry diapers, fussiness, or excessive crying in a child taking glycopyrrolate.

Less serious side effects may include:

• dry mouth;

• vomiting;

• mild constipation;

• stuffy nose, sinus pain; or

• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Antimuscarinic; a synthetic quaternary ammonium compound.a b c